Search results for: Karsten Haupt

Items from 1 to 20 out of 86 results

article

Tailoring a Dress to Single Protein Molecules: Proteins Can Do It Themselves through Localized Photo‐Polymerization and Molecular Imprinting

Alessandra Maria Bossi, Karsten Haupt

Chemistry – A European Journal > 26 > 64 > 14556 - 14559

Molecularly imprinted polymer nanoparticles (MIP NPs) are antibody‐like recognition materials prepared by a template‐assisted synthesis. MIP NPs able to target biomolecules, like proteins, are under the spotlight for their great potential in medicine, but efficiently imprinting biological templates is still very challenging. Here we propose generating a molecular imprint in single NPs, by photochemically...

article

Chemical Antibody Mimics Inhibit Cadherin‐Mediated Cell–Cell Adhesion: A Promising Strategy for Cancer Therapy

Paulina X. Medina Rangel, Elena Moroni, Franck Merlier, Levi A. Gheber, more

Angewandte Chemie > 132 > 7 > 2838 - 2844

One of the most promising strategies to treat cancer is the use of therapeutic antibodies that disrupt cell–cell adhesion mediated by dysregulated cadherins. The principal site where cell–cell adhesion occurs encompasses Trp2 found at the N‐terminal region of the protein. Herein, we employed the naturally exposed highly conserved peptide Asp1‐Trp2‐Val3‐Ile4‐Pro5‐Pro6‐Ile7, as epitope to prepare molecularly...

article

Chemical Antibody Mimics Inhibit Cadherin‐Mediated Cell–Cell Adhesion: A Promising Strategy for Cancer Therapy

Paulina X. Medina Rangel, Elena Moroni, Franck Merlier, Levi A. Gheber, more

Angewandte Chemie International Edition > 59 > 7 > 2816 - 2822

article

A Light‐Triggerable Nanoparticle Library for the Controlled Release of Non‐Coding RNAs

Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez‐Balsa, more

Angewandte Chemie > 132 > 5 > 2001 - 2007

RNA‐based therapies offer a wide range of therapeutic interventions including the treatment of skin diseases; however, the strategies to efficiently deliver these biomolecules are still limited due to obstacles related to the cellular uptake and cytoplasmic delivery. Herein, we report the synthesis of a triggerable polymeric nanoparticle (NP) library composed of 160 formulations, presenting physico‐chemical...

article

A Light‐Triggerable Nanoparticle Library for the Controlled Release of Non‐Coding RNAs

Josephine Blersch, Vitor Francisco, Catarina Rebelo, Adrian Jiménez‐Balsa, more

Angewandte Chemie International Edition > 59 > 5 > 1985 - 1991

article

Direct and sensitive determination of trypsin in human urine using a water-soluble signaling fluorescent molecularly imprinted polymer nanoprobe

Jingjing Xu, Elise Prost, Karsten Haupt, Bernadette Tse Sum Bui

Sensors and Actuators B: Chemical > 2018 > 258 > C > 10-17

A molecularly imprinted polymer (MIP) for biosensing trypsin is prepared by incorporating a benzamidine-based signaling fluorescent monomer during its synthesis. Binding to trypsin results in a 100-fold fluorescence enhancement when the MIP is excited with UV light. The assay can be performed by simply mixing a small amount of water-soluble MIP (100μg) and trypsin together in a quartz cuvette, followed...

article

Development of a QCM-D biosensor for Ochratoxin A detection in red wine

Aleksandra Karczmarczyk, Karsten Haupt, Karl-Heinz Feller

Talanta > 2017 > 166 > C > 193-197

Ochratoxin A (OTA), a highly toxic compound, is one of the most widely spread mycotoxins that contaminates a large variety of agricultural commodities. Due to its presence in the food chain, it imposes a hazard on both human and animal health. Therefore, there is a need for precise, fast and simple methods for toxin quantification. Herein, a novel sensor based on a quartz crystal microbalance with...

article

Enzyme‐Initiated Free‐Radical Polymerization of Molecularly Imprinted Polymer Nanogels on a Solid Phase with an Immobilized Radical Source

Mira Daoud Attieh, Yi Zhao, Assem Elkak, Aude Falcimaigne‐Cordin, more

Angewandte Chemie International Edition > 56 > 12 > 3339 - 3343

An enzyme‐mediated synthetic approach is described for the preparation of molecularly imprinted polymer nanoparticles (MIP‐NPs) in aqueous media. Horseradish peroxidase (HRP) was used to initiate the polymerization of methacrylate or vinyl monomers and cross‐linkers by catalyzing the generation of free radicals. To prevent entrapment of the enzyme in the cross‐linked polymer, and to enable it to be...

article

Enzyme‐Initiated Free‐Radical Polymerization of Molecularly Imprinted Polymer Nanogels on a Solid Phase with an Immobilized Radical Source

Mira Daoud Attieh, Yi Zhao, Assem Elkak, Aude Falcimaigne‐Cordin, more

Angewandte Chemie > 129 > 12 > 3387 - 3391

article

Fluorescent molecularly imprinted polymers as plastic antibodies for selective labeling and imaging of hyaluronan and sialic acid on fixed and living cells

Maria Panagiotopoulou, Stephanie Kunath, Paulina Ximena Medina-Rangel, Karsten Haupt, more

Biosensors and Bioelectronics > 2017 > 88 > C > 85-93

Altered glycosylation levels or distribution of sialic acids (SA) or hyaluronan in animal cells are indicators of pathological conditions like infection or malignancy. We applied fluorescently-labeled molecularly imprinted polymer (MIP) particles for bioimaging of fixed and living human keratinocytes, to localize hyaluronan and sialylation sites. MIPs were prepared with the templates D-glucuronic...

article

Molecularly imprinted polymer nanomaterials and nanocomposites by controlled/living radical polymerization

Selim Beyazit, Bernadette Tse Sum Bui, Karsten Haupt, Carlo Gonzato

Progress in Polymer Science > 2016 > 62 > Complete > 1-21

Since the pioneering work of Wulff and Mosbach more than 30 years ago, molecular imprinting of synthetic polymers has emerged as a robust and convenient way for synthesizing polymeric receptor materials bearing specific recognition sites for target molecules. The resulting materials, molecularly imprinted polymers (MIPs), are therefore commonly referred to as ‘plastic antibodies’. They are obtained...

article

Solid-phase extraction of betanin and isobetanin from beetroot extracts using a dipicolinic acid molecularly imprinted polymer

Sofia Nestora, Franck Merlier, Elise Prost, Karsten Haupt, more

Journal of Chromatography A > 2016 > 1465 > C > 47-54

Betanin is a natural pigment with significant antioxidant and biological activities currently used as food colorant. The isolation of betanin is problematic due to its instability. In this work, we developed a fast and economic procedure based on molecularly imprinted solid-phase extraction (MISPE) for the selective clean-up of betanin and its stereoisomer isobetanin from beetroot extracts. Dipicolinic...

article

Biocompatibility and internalization of molecularly imprinted nanoparticles

Francesco Canfarotta, Alicia Waters, Robyn Sadler, Paul McGill, more

Nano Research > 2016 > 9 > 11 > 3463-3477

Molecularly imprinted polymers (MIP) are receiving increasing attention thanks to their robustness, stability, and inexpensive manufacture compared with their bio-analogues such as antibodies. The molecular imprinting process can be defined as the generation of molecular recognition sites in a synthetic polymer. The template-derived sites created within a polymeric matrix allow MIPs (often referred...

article

Rapid Prototyping of Chemical Microsensors Based on Molecularly Imprinted Polymers Synthesized by Two‐Photon Stereolithography

Laura Piedad Chia Gomez, Arnaud Spangenberg, Xuan‐Anh Ton, Yannick Fuchs, more

Advanced Materials > 28 > 28 > 5931 - 5937

Two‐photon stereolithography is used for rapid prototyping of submicrometre molecularly imprinted polymer‐based 3D structures. The structures are evaluated as chemical sensing elements and their specific recognition properties for target molecules are confirmed. The 3D design capability is exploited and highlighted through the fabrication of an all‐organic molecularly imprinted polymeric microelectromechanical...

article

Molecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging

Maria Panagiotopoulou, Yolanda Salinas, Selim Beyazit, Stephanie Kunath, more

Angewandte Chemie > 128 > 29 > 8384 - 8388

Advanced tools for cell imaging are of great interest for the detection, localization, and quantification of molecular biomarkers of cancer or infection. We describe a novel photopolymerization method to coat quantum dots (QDs) with polymer shells, in particular, molecularly imprinted polymers (MIPs), by using the visible light emitted from QDs excited by UV light. Fluorescent core–shell particles...

article

Molecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging

Maria Panagiotopoulou, Yolanda Salinas, Selim Beyazit, Stephanie Kunath, more

Angewandte Chemie International Edition > 55 > 29 > 8244 - 8248

article

A New Versatile Water‐Soluble Iniferter Platform for the Preparation of Molecularly Imprinted Nanoparticles by Photopolymerisation in Aqueous Media

Paolo Bonomi, Mira Daoud Attieh, Carlo Gonzato, Karsten Haupt

Chemistry – A European Journal > 22 > 29 > 10150 - 10154

The multi‐step synthesis of a new water‐soluble dithiocarbamate iniferter platform for the preparation of nanoparticles and ‐gels in aqueous solvents by photoinduced living‐radical polymerisation is described herein. The water solubility of the dithiocarbamate iniferter was achieved by incorporating two unprotected glucose units into the iniferter structure by copper(I)‐catalysed azide–alkyne cycloaddition...

article

Plastic Antibodies for Cosmetics: Molecularly Imprinted Polymers Scavenge Precursors of Malodors

Sofia Nestora, Franck Merlier, Selim Beyazit, Elise Prost, more

Angewandte Chemie > 128 > 21 > 6360 - 6364

Molecularly imprinted polymers (MIPs) are synthetic antibody mimics capable of specific molecular recognition. Advantageously, they are more stable, easy to tailor for a given application and less expensive than antibodies. These plastic antibodies are raising increasing interest and one relatively unexplored domain in which they could outplay these advantages particularly well is cosmetics. Here,...

article

Plastic Antibodies for Cosmetics: Molecularly Imprinted Polymers Scavenge Precursors of Malodors

Sofia Nestora, Franck Merlier, Selim Beyazit, Elise Prost, more

Angewandte Chemie International Edition > 55 > 21 > 6252 - 6256

chapter

Molecularly Imprinted Polymers as Recognition Elements in Sensors

Karsten Haupt

Springer Series on Chemical Sensors and Biosensors > Ultrathin Electrochemical Chemo- and Biosensors > Receptors > 23-39

The technique of molecular imprinting allows for the formation of specific recognition sites in synthetic polymers through the use of templates or imprint molecules. These recognition sites mimic the binding sites of biological receptor molecules such as antibodies and enzymes. Molecularly imprinted polymers can therefore be used in applications based on specific molecular binding events, such as...

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INFONA - science communication portal

Search results for: Karsten Haupt

Tailoring a Dress to Single Protein Molecules: Proteins Can Do It Themselves through Localized Photo‐Polymerization and Molecular Imprinting

Chemical Antibody Mimics Inhibit Cadherin‐Mediated Cell–Cell Adhesion: A Promising Strategy for Cancer Therapy

Chemical Antibody Mimics Inhibit Cadherin‐Mediated Cell–Cell Adhesion: A Promising Strategy for Cancer Therapy

A Light‐Triggerable Nanoparticle Library for the Controlled Release of Non‐Coding RNAs

A Light‐Triggerable Nanoparticle Library for the Controlled Release of Non‐Coding RNAs

Direct and sensitive determination of trypsin in human urine using a water-soluble signaling fluorescent molecularly imprinted polymer nanoprobe

Development of a QCM-D biosensor for Ochratoxin A detection in red wine

Enzyme‐Initiated Free‐Radical Polymerization of Molecularly Imprinted Polymer Nanogels on a Solid Phase with an Immobilized Radical Source

Enzyme‐Initiated Free‐Radical Polymerization of Molecularly Imprinted Polymer Nanogels on a Solid Phase with an Immobilized Radical Source

Fluorescent molecularly imprinted polymers as plastic antibodies for selective labeling and imaging of hyaluronan and sialic acid on fixed and living cells

Molecularly imprinted polymer nanomaterials and nanocomposites by controlled/living radical polymerization

Solid-phase extraction of betanin and isobetanin from beetroot extracts using a dipicolinic acid molecularly imprinted polymer

Biocompatibility and internalization of molecularly imprinted nanoparticles

Rapid Prototyping of Chemical Microsensors Based on Molecularly Imprinted Polymers Synthesized by Two‐Photon Stereolithography

Molecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging

Molecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging

A New Versatile Water‐Soluble Iniferter Platform for the Preparation of Molecularly Imprinted Nanoparticles by Photopolymerisation in Aqueous Media

Plastic Antibodies for Cosmetics: Molecularly Imprinted Polymers Scavenge Precursors of Malodors

Plastic Antibodies for Cosmetics: Molecularly Imprinted Polymers Scavenge Precursors of Malodors

Molecularly Imprinted Polymers as Recognition Elements in Sensors

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