Search results for: Koon-Gee Neoh

Items from 1 to 20 out of 96 results

article

Restriction of in vivo infection by antifouling coating on urinary catheter with controllable and sustained silver release: a proof of concept study

Kedar Diwakar Mandakhalikar, Rong Wang, Juwita N. Rahmat, Edmund Chiong, more

BMC Infectious Diseases > 2018 > 18 > 1 > 1-9

Background Catheter Associated Urinary Tract Infections are among the most common urological infections world-wide. Bacterial biofilms and encrustation cause significant complications in patients with urinary catheters. The objective of the study is to demonstrate the efficacy and safety of an anti-microbial and anti-encrustation silver nanoparticle (AgNP) coating on silicone urinary catheter in two...

article

Electrical stimulation of adipose‐derived mesenchymal stem cells and endothelial cells co‐cultured in a conductive scaffold for potential orthopaedic applications

Jieyu Zhang, Koon Gee Neoh, En‐Tang Kang

Journal of Tissue Engineering and Regenerative Medicine > 12 > 4 > 878 - 889

Electrical stimulation (ES) has emerged as a useful tool to regulate cell behaviour, but the effect of ES on mesenchymal stem cell (MSC)/vasculogenic cell co‐culture has not been investigated. Herein, human adipose‐derived MSCs (AD‐MSCs) and umbilical vein endothelial cells (HUVECs) were co‐cultured in an electrically conductive polypyrrole/chitosan scaffold. Compared with AD‐MSC monoculture, calcium...

article

Fabrication of conductive carbon nanomaterial from carbonaceous waste

Wenlin Yvonne Lin, Koon Gee Neoh, Shin Nuo Koh, Chi Hwa Wang

Energy Procedia > 2017 > 143 > C > 487-493

The fabrication of conductive carbon nanomaterial has attracted extensive research due to its promising potential in energy application. However, the conventional fabrication methods, e.g. chemical vapour deposition, are expensive due to high energy consumption, which makes it both economically and environmentally unsustainable. The concept of using carbonaceous waste as a precursor for growing carbon...

article

Methoxy group substitution on catechol ring of dopamine facilitates its polymerization and formation of surface coatings

Jieyu Zhang, Yong Shung Cheah, Sridhar Santhanakrishnan, Koon Gee Neoh, more

Polymer > 2017 > 116 > C > 5-15

Deposition of polydopamine on substrates is a facile and effective method of surface modification and the deposited polydopamine can reduce silver ions to form silver nanoparticles (AgNPs) for antibacterial applications. However, polydopamine deposition is a time-consuming process that usually requires 24 h to produce a dense surface coating. Since oxidation of dopamine is critical for its polymerization,...

article

Variation of household electricity consumption and potential impact of outdoor PM2.5 concentration: A comparison between Singapore and Shanghai

Siming You, Koon Gee Neoh, Yen Wah Tong, Yanjun Dai, more

Applied Energy > 2017 > 188 > C > 475-484

The auto-regressive distributed lag (ARDL) bound testing approach was used to study the relationships between the monthly household electricity consumption and outdoor PM_2.5 concentration with the consideration of ambient temperature and the number of rainy days for Singapore and Shanghai. It is shown that there are significant long-run relationships between the household electricity consumption and...

article

Immobilization of alendronate on titanium via its different functional groups and the subsequent effects on cell functions

Dong Zheng, Koon Gee Neoh, En-Tang Kang

Journal of Colloid and Interface Science > 2017 > 487 > C > 1-11

Immobilization of alendronate on orthopedic implants offers the possibility of enhancing osteogenesis without potentially adverse effects associated with systemic administration of this drug. In this work, alendronate was immobilized on titanium (Ti) via either its phosphate (Method 1) or amino (Method 2) groups, and responses of osteoblasts and human mesenchymal stem cells (hMSCs) on these surfaces...

article

Toxicity assessment of carbon black waste: A by-product from oil refineries

Xu Zhen, Wei Cheng Ng, Fendy, Yen Wah Tong, more

Journal of Hazardous Materials > 2017 > 321 > C > 600-610

In Singapore, approximately 30t/day of carbon-based solid waste are produced from petrochemical processes. This carbon black waste has been shown to possess physical properties that are characteristic of a good adsorbent such as high external surface area. Therefore, there is a growing interest to reutilize and process this carbon black waste into secondary materials such as adsorbents. However, the...

article

Chemically treated carbon black waste and its potential applications

Pengwei Dong, Thawatchai Maneerung, Wei Cheng Ng, Xu Zhen, more

Journal of Hazardous Materials > 2017 > 321 > C > 62-72

In this work, carbon black waste – a hazardous solid residue generated from gasification of crude oil bottom in refineries – was successfully used for making an absorbent material. However, since the carbon black waste also contains significant amounts of heavy metals (especially nickel and vanadium), chemical leaching was first used to remove these hazardous impurities from the carbon black waste...

article

On the association between outdoor PM2.5 concentration and the seasonality of tuberculosis for Beijing and Hong Kong

Siming You, Yen Wah Tong, Koon Gee Neoh, Yanjun Dai, more

Environmental Pollution > 2016 > 218 > C > 1170-1179

Tuberculosis (TB) is still a serious public health problem in various countries. One of the long-elusive but critical questions about TB is what the risk factors are and how they contribute for its seasonality. An ecologic study was conducted to examine the association between the variation of outdoor PM_2.5 concentration and the TB seasonality based on the monthly TB notification and PM_2.5 concentration...

article

The chemical reactivities of DOPA and dopamine derivatives and their regioselectivities upon oxidative nucleophilic trapping

Yong Shung Cheah, Sridhar Santhanakrishnan, Michael B. Sullivan, Koon Gee Neoh, more

Tetrahedron > 2016 > 72 > 41 > 6543-6550

The chemical reactivities of four catecholamines, N-acetyl dopamine (NADA) and its dehydro derivative (NAΔDA), N-acetyl 3,4-dihydroxy-phenylalanine methyl ester (NADOPAME) and its dehydro derivative (NAΔDOPAME), under oxidative nucleophilic trapping and polymerisation conditions were compared and contrasted. Despite their structural similarities, varying reactivities and regioselectivities for oxidative...

article

Antifouling coatings based on covalently cross-linked agarose film via thermal azide-alkyne cycloaddition

Li Qun Xu, Dicky Pranantyo, Koon-Gee Neoh, En-Tang Kang, more

Colloids and Surfaces B: Biointerfaces > 2016 > 141 > C > 65-73

Coatings based on thin films of agarose-poly(ethylene glycol) (Agr-PEG) cross-linked systems are developed as environmentally-friendly and fouling-resistant marine coatings. The Agr-PEG cross-linked systems were prepared via thermal azide-alkyne cycloaddition (AAC) using azido-functionalized Agr (AgrAz) and activated alkynyl-containing poly(2-propiolamidoethyl methacrylate-co-poly(ethylene glycol)methyl...

article

Rapid toxicity screening of gasification ashes

Xu Zhen, Le Rong, Wei Cheng Ng, Cynthia Ong, more

Waste Management > 2016 > 50 > C > 93-104

The solid residues including bottom ashes and fly ashes produced by waste gasification technology could be reused as secondary raw materials. However, the applications and utilizations of these ashes are very often restricted by their toxicity. Therefore, toxicity screening of ash is the primary condition for reusing the ash. In this manuscript, we establish a standard for rapid screening of gasification...

article

Co-delivery of peptide-modified cisplatin and doxorubicin via mucoadhesive nanocapsules for potential synergistic intravesical chemotherapy of non-muscle-invasive bladder cancer

Shengjie Lu, Liqun Xu, En Tang Kang, Ratha Mahendran, more

European Journal of Pharmaceutical Sciences > 2016 > 84 > C > 103-115

Synergistic effect against UMUC3 bladder cancer cells was demonstrated via a “two-in-one” combination of doxorubicin (Dox) and peptide-modified cisplatin (Pt–ALy) loaded in positively charged mucoadhesive chitosan–polymethacrylic acid (CM) nanocapsules. The in vitro killing efficacy of the dual drug-loaded nanocapsules (CM–Dox–PtALy) against UMUC3 cells after 4h- and 72h-treatment is much higher (with...

article

Electrical stimulation of adipose-derived mesenchymal stem cells in conductive scaffolds and the roles of voltage-gated ion channels

Jieyu Zhang, Min Li, En-Tang Kang, Koon Gee Neoh

Acta Biomaterialia > 2016 > 32 > C > 46-56

Since electrical stimulation (ES) can significantly accelerate bone healing, a conductive scaffold that can deliver ES locally at the defect site is desirable for bone defect therapy. Herein, an electrically conductive scaffold was prepared via incorporation of polypyrrole (PPY) in a polycaprolactone (PCL) template scaffold. In vitro tests with mouse osteoblasts indicate that the PPY/PCL scaffold...

article

Sugar-Grafted Cyclodextrin Nanocarrier as a “Trojan Horse” for Potentiating Antibiotic Activity

Min Li, Koon Gee Neoh, Liqun Xu, Liang Yuan, more

Pharmaceutical Research > 2016 > 33 > 5 > 1161-1174

Purpose The use of “Trojan Horse” nanocarriers for antibiotics to enhance the activity of antibiotics against susceptible and resistant bacteria is investigated. Methods Antibiotic carriers (CD-MAN and CD-GLU) are prepared from β-cyclodextrin grafted with sugar molecules (D-mannose and D-glucose, respectively) via azide-alkyne click reaction. The sugar molecules serve as a chemoattractant enticing...

article

Bifunctional coating based on carboxymethyl chitosan with stable conjugated alkaline phosphatase for inhibiting bacterial adhesion and promoting osteogenic differentiation on titanium

Dong Zheng, Koon Gee Neoh, En-Tang Kang

Applied Surface Science > 2016 > 360 > PA > 86-97

In this work, alkaline phosphatase (ALP) was covalently immobilized on carboxymethyl chitosan (CMCS)-coated polydopamine (PDA)-functionalized Ti to achieve a bifunctional surface. Our results showed ∼89% reduction in Staphylococcus epidermidis adhesion on this surface compared to that on pristine Ti. The ALP-modified Ti supported cell proliferation, and significantly enhanced cellular ALP activity...

article

Surface charge control for zwitterionic polymer brushes: Tailoring surface properties to antifouling applications

Shanshan Guo, Dominik Jańczewski, Xiaoying Zhu, Robert Quintana, more

Journal of Colloid and Interface Science > 2015 > 452 > C > 43-53

Electrostatic interactions play an important role in adhesion phenomena particularly for biomacromolecules and microorganisms. Zero charge valence of zwitterions has been claimed as the key to their antifouling properties. However, due to the differences in the relative strength of their acid and base components, zwitterionic materials may not be charge neutral in aqueous environments. Thus, their...

article

Quantification of aldehyde terminated heparin by SEC-MALLS–UV for the surface functionalization of polycaprolactone biomaterials

Scott A. Irvine, Terry W.J. Steele, Ramya Bhuthalingam, Min Li, more

Colloids and Surfaces B: Biointerfaces > 2015 > 132 > C > 253-263

A straight forward strategy of heparin surface grafting employs a terminal reactive-aldehyde group introduced through nitrous acid depolymerization. An advanced method that allows simultaneously monitoring of both heparin molar mass and monomer/aldehyde ratio by size exclusion chromatography, multi-angle laser light scattering and UV-absorbance (SEC-MALLS–UV) has been developed to improve upon heparin...

article

Mucoadhesive polyacrylamide nanogel as a potential hydrophobic drug carrier for intravesical bladder cancer therapy

Shengjie Lu, Koon Gee Neoh, En-Tang Kang, Ratha Mahendran, more

European Journal of Pharmaceutical Sciences > 2015 > 72 > Complete > 57-68

In this paper, amine-functionalized polyacrylamide nanogels (PAm-NH ₂ ) loaded with docetaxel (DTX) were evaluated as a mucoadhesive and sustained intravesical drug delivery (IDD) system for potential bladder cancer therapy. Nanogels have not been applied for such therapy before. The mucoadhesiveness of the PAm-NH ₂ nanogels, which is a critical factor for IDD application, was investigated...

article

Antifouling coating with controllable and sustained silver release for long‐term inhibition of infection and encrustation in urinary catheters

Rong Wang, Koon Gee Neoh, En‐Tang Kang, Paul Anantharajah Tambyah, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 103 > 3 > 519 - 528

Urinary tract infections constitute a large proportion of nosocomial infections, and the urinary catheter is the most important predisposing factor. Encrustation induced by urease‐producing uropathogens like Proteus mirabilis causes further complications. In the present work, a strategy for controllable and sustained release of silver over several weeks has been developed for combating bacterial infection...

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Keywords

OSTEOBLAST (8)
SURFACE MODIFICATION (6)
ATRP (5)
BACTERIAL ADHESION (5)
POLYPYRROLE (5)
ANTIFOULING (4)
CARBOXYMETHYL CHITOSAN (4)
CHITOSAN (4)
DOXORUBICIN (4)
ELECTRICAL STIMULATION (4)
HEPARIN (4)
MRI (4)
REDUCED GRAPHENE OXIDE (4)
TITANIUM (4)
ANTIBACTERIAL (3)
DENTINE (3)
GRAPHENE OXIDE (3)
POLYMERS (3)
SILVER NANOPARTICLES (3)
STEM CELL (3)
AGAROSE (2)
APOPTOSIS (2)
BACTERIAL COLONIZATION (2)
BIOFILM (2)
BIOMIMETIC (2)
BLADDER CANCER (2)
DIRECT CURRENT (2)
ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (EIS) (2)
FLUORESCENCE (2)
GASIFICATION (2)
INFECTION (2)
IRON OXIDE NANOPARTICLES (2)
MACROPHAGE EVASION (2)
MEMORY DEVICES (2)
METHOTREXATE (2)
NANOPARTICLES (2)
PH-RESPONSIVE (2)
PM2.5 (2)
REACTIVE OXYGEN SPECIES (2)
REMINERALIZATION (2)
REWRITABLE MEMORY (2)
SILICONE (2)
STABILITY (2)
SURFACE-INITIATED ATRP (2)
TOXICITY EVALUATION (2)
VEGF (2)
1,3‐DIPOLAR CYCLOADDITION (1)
ACTIVE TARGETING (1)
ADIPOSE-DERIVED MESENCHYMAL STEM CELLS (1)
ADIPOSE‐DERIVED MESENCHYMAL STEM CELLS (1)
ADSORPTION (1)
AFFINITY INTERACTION (1)
ALENDRONATE (1)
ALKALI (1)
ALKALINE PHOSPHATASE (1)
ANATASE (1)
ANILINE (1)
ANTI-FOULING (1)
ANTIBACTERIAL COATING (1)
ANTIBACTERIALS (1)
ANTIBIOTIC NANOCARRIER (1)
ANTICANCER (1)
ANTIMICROBIAL (1)
APTAMER (1)
APTAMERS (1)
ARDL (1)
AUTOLYSIS (1)
BACTERIAL ADHERENCE (1)
BACTERIAL-INDUCED DEMINERALIZATION (1)
BACTERICIDAL (1)
BACTERICIDAL EFFECTS (1)
BIFUNCTIONAL COATING (1)
BIOCOMPATIBILITY (1)
BIOCORROSION (1)
BIODEGRADABLE (1)
BIOELECTRIC EFFECT (1)
BIOLOGICAL APPLICATIONS OF POLYMERS (1)
BISPHOSPHONATE (1)
BISTABLE SWITCHING (1)
BMP PEPTIDE (1)
BMP-2 (1)
BMP‐2 (1)
BONE IMPLANTS (1)
BOTTOM ASH (1)
BOTTOM ASHES (1)
BREAST CANCER (1)
CANCER CELLS (1)
CANCER CHEMOTHERAPY (1)
CANCER TARGETING (1)
CAPACITANCE (1)
CARBANACEOUS WASTE (1)
CARBON BLACK (1)
CARBON BLACK WASTE (1)
CATECHOLAMINE (1)
CATHETER (1)
CATHETER ASSOCIATED URINARY TRACT INFECTIONS (1)
CAUTI (1)
CELL TARGETING (1)
CELLULAR CROSSTALK (1)
CHARGE TRANSPORT (1)
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Data set

Elsevier (55)
Wiley (19)
ACS (17)
Springer (5)

Journal

Biomaterials (13)
Polymer (7)
Journal of Colloid And Interface Science (5)
Langmuir (5)
Chemistry – A European Journal (4)
Macromolecules (4)
European Journal of Pharmaceutical Sciences (3)
Journal of Colloid and Interface Science (3)
Journal of Materials Science: Materials in Medicine (3)
Advanced Functional Materials (2)
Biotechnology and Bioengineering (2)
Chemistry of Materials (2)
Colloids and Surfaces B: Biointerfaces (2)
Journal of Biomedical Materials Research Part B: Applied Biomaterials (2)
Journal of Dentistry (2)
Journal of Hazardous Materials (2)
Macromolecular Rapid Communications (2)
Polymer Degradation and Stability (2)
Progress in Polymer Science (2)
Waste Management (2)
ACS Applied Materials & Interfaces (1)
ACS Nano (1)
AIChE Journal (1)
Acta Biomaterialia (1)
Analytical Biochemistry (1)
Analytical Chemistry (1)
Applied Energy (1)
Applied Surface Science (1)
BMC Infectious Diseases (1)
Biomacromolecules (1)
Contrast Media & Molecular Imaging (1)
Energy Procedia (1)
Environmental Pollution (1)
Journal of Applied Polymer Science (1)
Journal of Endodontics (1)
Journal of Membrane Science (1)
Journal of Orthopaedic Research® (1)
Journal of Pharmaceutical Sciences (1)
Journal of Tissue Engineering and Regenerative Medicine (1)
Journal of the American Chemical Society (1)
Macromolecular Bioscience (1)
Materials Science & Engineering C (1)
Organic Electronics (1)
Pharmaceutical Research (1)
Sensors & Actuators: B. Chemical (1)
Tetrahedron (1)
The Journal of Physical Chemistry B (1)
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INFONA - science communication portal

Search results for: Koon-Gee Neoh

Restriction of in vivo infection by antifouling coating on urinary catheter with controllable and sustained silver release: a proof of concept study

Electrical stimulation of adipose‐derived mesenchymal stem cells and endothelial cells co‐cultured in a conductive scaffold for potential orthopaedic applications

Fabrication of conductive carbon nanomaterial from carbonaceous waste

Methoxy group substitution on catechol ring of dopamine facilitates its polymerization and formation of surface coatings

Variation of household electricity consumption and potential impact of outdoor PM2.5 concentration: A comparison between Singapore and Shanghai

Immobilization of alendronate on titanium via its different functional groups and the subsequent effects on cell functions

Toxicity assessment of carbon black waste: A by-product from oil refineries

Chemically treated carbon black waste and its potential applications

On the association between outdoor PM2.5 concentration and the seasonality of tuberculosis for Beijing and Hong Kong

The chemical reactivities of DOPA and dopamine derivatives and their regioselectivities upon oxidative nucleophilic trapping

Antifouling coatings based on covalently cross-linked agarose film via thermal azide-alkyne cycloaddition

Rapid toxicity screening of gasification ashes

Co-delivery of peptide-modified cisplatin and doxorubicin via mucoadhesive nanocapsules for potential synergistic intravesical chemotherapy of non-muscle-invasive bladder cancer

Electrical stimulation of adipose-derived mesenchymal stem cells in conductive scaffolds and the roles of voltage-gated ion channels

Sugar-Grafted Cyclodextrin Nanocarrier as a “Trojan Horse” for Potentiating Antibiotic Activity

Bifunctional coating based on carboxymethyl chitosan with stable conjugated alkaline phosphatase for inhibiting bacterial adhesion and promoting osteogenic differentiation on titanium

Surface charge control for zwitterionic polymer brushes: Tailoring surface properties to antifouling applications

Quantification of aldehyde terminated heparin by SEC-MALLS–UV for the surface functionalization of polycaprolactone biomaterials

Mucoadhesive polyacrylamide nanogel as a potential hydrophobic drug carrier for intravesical bladder cancer therapy

Antifouling coating with controllable and sustained silver release for long‐term inhibition of infection and encrustation in urinary catheters

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