Search results for: John P. Quinn

Items from 1 to 20 out of 86 results

article

Genome‐Wide Analysis of Structural Variants in Parkinson Disease

Kimberley J. Billingsley, Jinhui Ding, Pilar Alvarez Jerez, Anastasia Illarionova, more

Annals of Neurology > 93 > 5 > 1012 - 1022

Objective Identification of genetic risk factors for Parkinson disease (PD) has to date been primarily limited to the study of single nucleotide variants, which only represent a small fraction of the genetic variation in the human genome. Consequently, causal variants for most PD risk are not known. Here we focused on structural variants (SVs), which represent a major source of genetic variation...

article

Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila

Stephen F. Politano, Ryan R. Salemme, James Ashley, Javier A. López‐Rivera, more

Developmental Neurobiology > 79 > 4 > 335 - 349

The coordinated growth and development of synapses is critical for all aspects of neural circuit function and mutations that disrupt these processes can result in various neurological defects. Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway, regulate synaptic development in vertebrates and invertebrates. At the Drosophila larval...

article

Insights into the structural dynamics of the bacteriophage T7 DNA polymerase and its complexes

Damian J. Magill, John W. McGrath, Vincent O’Flaherty, John P. Quinn, more

Journal of Molecular Modeling > 2018 > 24 > 7 > 1-13

The T7 DNA polymerase is dependent on the host protein thioredoxin (trx) for its processivity and fidelity. Using all-atom molecular dynamics, we demonstrate the specific interactions between trx and the T7 polymerase, and show that trx docking to its binding domain on the polymerase results in a significant level of stability and exposes a series of basic residues within the domain that interact...

article

The Regulation of Monoamine Oxidase A Gene Expression by Distinct Variable Number Tandem Repeats

Maurizio Manca, Veridiana Pessoa, Ana Illera Lopez, Patrick T. Harrison, more

Journal of Molecular Neuroscience > 2018 > 64 > 3 > 459-470

The monoamine oxidase A (MAOA) uVNTR (upstream variable number tandem repeat) is one of the most often cited examples of a gene by environment interaction (GxE) in relation to behavioral traits. However, MAOA possesses a second VNTR, 500 bp upstream of the uVNTR, which is termed d- or distal VNTR. Furthermore, genomic analysis indicates that there are a minimum of two transcriptional start sites (TSSs)...

article

SVA retrotransposons as potential modulators of neuropeptide gene expression

Olympia Gianfrancesco, Vivien J. Bubb, John P. Quinn

Neuropeptides > 2017 > 64 > C > 3-7

Many facets of human behaviour are likely to have developed in part due to evolutionary changes in the regulation of neuropeptide and other brain-related genes. This has allowed species-specific expression patterns and unique epigenetic modulation in response to our environment, regulating response not only at the molecular level, but also contributing to differences in behaviour between individuals...

article

Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus

Olympia Gianfrancesco, Alix Warburton, David A. Collier, Vivien J. Bubb, more

Schizophrenia Research > 2017 > 184 > C > 109-115

Genome-wide association studies (GWAS) have identified a locus on chromosome 1p21.3 to be highly associated with schizophrenia. A microRNA, MIR137, within this locus has been proposed as the gene causally associated with schizophrenia, due to its known role as a regulator of neuronal development and function. However, the involvement of other genes within this region, including DPYD (dihydropyrimidine...

article

Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice

Éva Borbély, Zsófia Hajna, Liza Nabi, Bálint Scheich, more

Brain, Behavior, and Immunity > 2017 > 59 > C > 219-232

The tachykinin NK1 receptor was suggested to be involved in psychiatric disorders, but its antagonists have failed to be effective as antidepressants in clinical trials. Hemokinin-1 (HK-1), the newest tachykinin, is present in several brain regions and activates the NK1 receptor similarly to substance P (SP), but acts also through other mechanisms. Therefore, we investigated the roles of the Tac4...

article

Identification and Potential Regulatory Properties of Evolutionary Conserved Regions (ECRs) at the Schizophrenia-Associated MIR137 Locus

Olympia Gianfrancesco, Daniel Griffiths, Paul Myers, David A. Collier, more

Journal of Molecular Neuroscience > 2016 > 60 > 2 > 239-247

Genome-wide association studies (GWAS) have identified a region at chromosome 1p21.3, containing the microRNA MIR137, to be among the most significant associations for schizophrenia. However, the mechanism by which genetic variation at this locus increases risk of schizophrenia is unknown. Identifying key regulatory regions around MIR137 is crucial to understanding the potential role of this gene...

article

Gender and estrous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine

Vládia Célia Moreira Borella, Mary V. Seeman, Rafaela Carneiro Cordeiro, Júnia Vieira dos Santos, more

Developmental Neurobiology > 76 > 5 > 519 - 532

Neonatal N‐methyl‐D‐aspartate (NMDA) receptor blockade in rodents triggers schizophrenia (SCZ)‐like alterations during adult life. SCZ is influenced by gender in age of onset, premorbid functioning, and course. Estrogen, the hormone potentially driving the gender differences in SCZ, is known to present neuroprotective effects such as regulate oxidative pathways and the expression of brain‐derived...

article

Microbial transformations in phosphonate biosynthesis and catabolism, and their importance in nutrient cycling

Jason P Chin, John W McGrath, John P Quinn

Current Opinion in Chemical Biology > 2016 > 31 > C > 50-57

Phosphorus cycling in the biosphere has traditionally been thought to involve almost exclusively transformations of the element in its pentavalent oxidation state. Recent evidence, however, suggests that a significant fraction of environmental phosphorus may exist in a more reduced form. Most abundant of these reduced phosphorus compounds are the phosphonates, with their direct carbon–phosphorus bonds,...

article

Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees

Éva Borbély, Katalin Sándor, Adrienn Markovics, Ágnes Kemény, more

Inflammation Research > 2016 > 65 > 9 > 725-736

Objective, design Mast cell tryptase (MCT) is elevated in arthritic joints, but its direct effects are not known. Here, we investigated MCT-evoked acute inflammatory and nociceptive mechanisms with behavioural, in vivo imaging and immunological techniques. Material and subjects Neurogenic inflammation involving capsaicin-sensitive afferents, transient receptor potential vanilloid 1 receptor (TRPV1),...

article

NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly diagnosed epilepsy

Alix Warburton, Fabio Miyajima, Kanvel Shazadi, Joanne Crossley, more

Epilepsy & Behavior > 2016 > 54 > C > 117-127

Cognitive dysfunction is a common comorbidity in people with epilepsy, but its causes remain unclear. It may be related to the etiology of the disorder, the consequences of seizures, or the effects of antiepileptic drug treatment. Genetics may also play a contributory role. We investigated the influence of variants in the genes encoding neuron-restrictive silencer factor (NRSF) and brain-derived neurotrophic...

article

Molecular signatures of mood stabilisers highlight the role of the transcription factor REST/NRSF

Alix Warburton, Abigail L. Savage, Paul Myers, David Peeney, more

Journal of Affective Disorders > 2015 > 172 > Complete > 63-73

The purpose of this study was to address the affects of mood modifying drugs on the transcriptome, in a tissue culture model, using qPCR arrays as a cost effective approach to identifying regulatory networks and pathways that might coordinate the cell response to a specific drug.We addressed the gene expression profile of 90 plus genes associated with human mood disorders using the StellARray™ qPCR...

article

Characterisation of multiple regulatory domains spanning the major transcriptional start site of the FUS gene, a candidate gene for motor neurone disease

Kejhal Khursheed, Thomas P. Wilm, Christine Cashman, John P. Quinn, more

Brain Research > 2015 > 1595 > C > 1-9

Fused-In-Sarcoma (FUS) is a candidate gene for neurological disorders including motor neurone disease and Parkinson׳s disease in addition to various types of cancer. Recently it has been reported that over expression of FUS causes motor neurone disease in mouse models hence mutations leading to changes in gene expression may contribute to the development of neurodegenerative disease. Genome evolutionary...

article

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Christopher L. Hendrickson, John P. Quinn, Nathan K. Kaiser, Donald F. Smith, more

Journal of The American Society for Mass Spectrometry > 2015 > 26 > 9 > 1626-1632

We describe the design and initial performance of the first 21 tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The 21 tesla magnet is the highest field superconducting magnet ever used for FT-ICR and features high spatial homogeneity, high temporal stability, and negligible liquid helium consumption. The instrument includes a commercial dual linear quadrupole trap front...

article

Role of neurokinin 1 receptors in dextran sulfate-induced colitis: studies with gene-deleted mice and the selective receptor antagonist netupitant

István Szitter, Erika Pintér, Anikó Perkecz, Ágnes Kemény, more

Inflammation Research > 2014 > 63 > 5 > 399-409

Objective and design The function of the neurokinin 1 (NK1) receptor was investigated in the DSS-induced mouse colitis model using NK1 receptor-deficient mice and the selective antagonist netupitant. Subjects Colitis was induced by oral administration of 20 mg/ml DSS solution for 7 days in C57BL/6 and Tacr1 KO animals (n = 5–7). Treatment During the induction, one-half of the C57BL/6 and Tacr1...

article

Mental health and behaviour

John P Quinn

Neuropeptides > 2013 > 47 > 6 > 361

article

Polymorphic variation as a driver of differential neuropeptide gene expression

John P. Quinn, Alix Warburton, Paul Myers, Abigail L. Savage, more

Neuropeptides > 2013 > 47 > 6 > 395-400

The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determined mechanisms established during life experiences. The latter underpins what is...

article

The effect of polyphosphate kinase gene deletion on polyhydroxyalkanoate accumulation and carbon metabolism in Pseudomonas putida KT2440

William T. Casey, Jasmina Nikodinovic‐Runic, Pilar Fonseca Garcia, Maciej W. Guzik, more

Environmental Microbiology Reports > 5 > 5 > 740 - 746

The primary enzyme involved in polyphosphate (polyP) synthesis, polyP kinase (ppk), has been deleted in Pseudomonas putida KT2440. This has resulted in a threefold to sixfold reduction in polyhydroxyalkanoate (PHA) accumulation compared with the wild type under conditions of nitrogen limitation, with either temperature or oxidative (H₂O₂) stress, when grown on glucose. The accumulation of PHA by Δppk...

article

Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases

L Silvia Munoz-Price, Laurent Poirel, Robert A Bonomo, Mitchell J Schwaber, more

The Lancet Infectious Diseases > 2013 > 13 > 9 > 785-796

Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria, especially K pneumoniae, although their precise epidemiology is diverse across countries and regions. The mortality described among patients infected with organisms positive for KPC is high, perhaps as a result...

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INFONA - science communication portal

Search results for: John P. Quinn

Genome‐Wide Analysis of Structural Variants in Parkinson Disease

Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila

Insights into the structural dynamics of the bacteriophage T7 DNA polymerase and its complexes

The Regulation of Monoamine Oxidase A Gene Expression by Distinct Variable Number Tandem Repeats

SVA retrotransposons as potential modulators of neuropeptide gene expression

Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus

Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice

Identification and Potential Regulatory Properties of Evolutionary Conserved Regions (ECRs) at the Schizophrenia-Associated MIR137 Locus

Gender and estrous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine

Microbial transformations in phosphonate biosynthesis and catabolism, and their importance in nutrient cycling

Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees

NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly diagnosed epilepsy

Molecular signatures of mood stabilisers highlight the role of the transcription factor REST/NRSF

Characterisation of multiple regulatory domains spanning the major transcriptional start site of the FUS gene, a candidate gene for motor neurone disease

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Role of neurokinin 1 receptors in dextran sulfate-induced colitis: studies with gene-deleted mice and the selective receptor antagonist netupitant

Mental health and behaviour

Polymorphic variation as a driver of differential neuropeptide gene expression

The effect of polyphosphate kinase gene deletion on polyhydroxyalkanoate accumulation and carbon metabolism in Pseudomonas putida KT2440

Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases

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