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Since the early work of Bernard Katz, the process of cellular chemical communication through exocytosis, quantal release, has been considered to be all or none. Recent evidence has shown exocytosis to be partial or “subquantal” at single‐cell model systems, but there is a need to understand this at communicating nerve cells. Partial release allows nerve cells to control the signal at the site of release...
Zinc, a suspected potentiator of learning and memory, is shown to affect exocytotic release and storage in neurotransmitter‐containing vesicles. Structural and size analysis of the vesicular dense core and halo using transmission electron microscopy was combined with single‐cell amperometry to study the vesicle size changes induced after zinc treatment and to compare these changes to theoretical predictions...
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