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Low transfection efficiency of chitosan limits its use as a non-viral vector for practical purposes. This study was designed to investigate the effect of fatty acyl chain length on physicochemical properties, pDNA binding affinity, cell uptake, and in vitro transfection efficiency of N-acyl chitosan (NAC). NAC polymers were synthesized by carbodiimide mediated coupling reaction of chitosan with n-hexanoic,...
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