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The Generalized Phase Contrast (GPC) method has been demonstrated to reshape light efficiently to match the input beam profile requirements of different illumination targets. A spatially coherent beam can be GPC-shaped into a variety of static and dynamic profiles to match e.g. fixed commercially available modulation systems or for more irregular and dynamic shapes such as found in advanced optogenetic...
Improving the resolution of biological research to the single-cell or sub-cellular level is of critical importance in a wide variety of processes and disease conditions. Most obvious are those linked to aging and cancer, many of which are dependent upon stochastic processes where individual, unpredictable failures or mutations in individual cells can lead to serious downstream conditions across the...
Generalized Phase Contrast (GPC) is an efficient method for generating speckle-free contiguous optical distributions. It has been used in applications such as optical manipulation, microscopy, optical cryptography and more contemporary biological applications such as twophoton optogenetics or neurophotonics.Among its diverse applications, simple efficient shapes for illumination or excitation happen...
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