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Matrix-assisted laser desorption ionization (MALDI)-ion mobility (IM)-time-of-flight (TOF) mass spectrometry (MS) has been applied to the analysis of enzymatically digested protein mixtures. The IM-TOF MS technique is rapid relative to other approaches to coupling separation methods with mass spectrometry (e.g., LC-MS, CE-MS, etc.), and MALDI-IM-TOF MS retains the advantage of reduced chemical noise...
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