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BackgroundThe Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) received five years' funding ($21 112 866) from the National Institutes of Health to compare carotid stenting to surgery for stroke prevention in 2500 randomized participants at 40 sites.
AimsHerein we evaluate the change in the CREST budget from a fixed to variable‐cost model and recommend strategies for the financial...
BackgroundRandomized clinical trials often encounter slow enrollment. Failing to meet sample size requirements has scientific, financial, and ethical implications.
AimsWe report interventions used to accelerate recruitment in a large multicenter clinical trial that was not meeting prespecified enrollment commitments.
MethodsThe Carotid Revascularization Endarterectomy vs. Stenting Trial began randomization...
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