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Background
IL‐37 is emerging as an anti‐inflammatory cytokine, particularly in innate inflammation. However, the role of IL‐37 in Th2‐mediated allergic lung inflammation remains uncertain. We sought to determine the role and the underlying mechanisms of IL‐37 in the development of house dust mites (HDM)‐induced murine asthma model.
Methods
We examined the effect of IL‐37 administration during the...
Elements are vital in airway mucosal physiology and pathology, but their distribution and levels in the mucosa remain unclear. This study uses the state‐of‐the‐art nuclear microscopy facility to map and quantify multiple elements in the histology sections of nasal mucosa from patients with nasal polyps or inverted papilloma. Our results demonstrate that P and Ca are the most abundant elements in mucosa...
Background
Aberrant epithelial remodeling with the ectopic expression of p63 (basal cell markers) is an important pathologic phenomenon seen in chronically inflamed airway epithelium such as in nasal polyps (NPs).
Methods
Biopsies were obtained from 55 NP patients and 18 healthy controls (inferior turbinate). Among NP patients, 15 were treated with oral and nasal steroids, so that two sets of NP...
BackgroundAllergic Rhinitis Control Test (ARCT) has been validated for assessing allergic rhinitis (AR) control and identifying severe AR. The aim of the study was to assess the ARCT questionnaire as a tool for stepwise pharmacotherapy.
MethodsA standard pharmacotherapy regimen from Step 1 (oral second‐generation H1 antihistamine as needed) to Step 5 (oral corticosteroid) was carried out prospectively...
BackgroundNeonatal Bacillus Calmette–Guérin (BCG) vaccination induces vigorous T‐helper type 1 (Th1) responses and inhibits allergy‐related airway dysfunction, but the exact mechanisms remain unclear. The objective of this study was to address where the Th1 cells induced by neonatal BCG vaccination are generated and stored, and how they are recruited into the inflamed airway for the prevention of...
BackgroundTransforming growth factor (TGF)‐β1 produced in airway epithelia has been suggested as a contributor to the airway remodeling observed in asthma patients. The protein tyrosine phosphatase SHP2 is a demonstrable modulator of TGF‐β1 production and thus a potential regulator of airway remodeling.
ObjectivesTo define the signal event by which SHP2 regulates asthmatic responses in airway epithelial...
BackgroundNasal polyposis (NP) is a Th2‐skewed inflammatory disorder, but it is unclear what role regulatory T cells (T‐reg) play in disease pathology. We investigated the expression profiles of T‐reg and T‐helper‐cell‐associated genes and their response to glucocorticosteroid (GC) treatment in Chinese patients with NP.
MethodsBiopsies were obtained from 29 non‐treated NP patients for comparison...
BackgroundTreatment options for food allergy remain limited. Development of novel approaches for the prevention and/or treatment of severe peanut allergy and other food allergies is urgently needed. The objective of this study was to test whether skin application of food allergen can be used as a prophylactic and/or therapeutic intervention for food allergy.
MethodsBalb/C mice were given 5 weekly...
To cite this article: Tian L, Li W, Wang J, Zhang Y, Zheng Y, Qi H, Guo X, Zhang Y, Ma D, Shen H, Wang Y. The CKLF1‐C19 peptide attenuates allergic lung inflammation by inhibiting CCR3‐ and CCR4‐mediated chemotaxis in a mouse model of asthma. Allergy 2011; 66: 287–297.
AbstractBackground: Human chemokine‐like factor 1 (CKLF1) is a functional ligand for human CCR4, which is highly expressed on Th2...
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