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A robust and validated LC-MS-MS quantitative method, using column switching and mutiple reaction monitoring was developed for the analysis of risperidone (RIS) and 9-hydroxyrisperidone in human plasma and saliva. The analytical range was 1-100ng/ml. The method used 25μl of sample precipitated with 75μl of acetonitrile containing internal standard (R068808). Analyses were conducted on a PE Sciex API-III+triple...
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