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• AmmTX3, a member of the α‐KTX15 family of scorpion toxins, efficiently and specifically blocks the subthreshold‐operating A‐type K+ current in cerebellar granule neurons from wild‐type mice but not in neurons from mice lacking the Kv4 channel‐associated protein DPP6.
• In heterologous cells high‐affinity blockade of Kv4.2 and Kv4.3 channels by AmmTX3 requires the presence of the associated proteins...
Although the extracellular matrix plays an important role in regulating use-dependent synaptic plasticity, the underlying molecular mechanisms are poorly understood. Here we examined the synaptic function of hyaluronic acid (HA), a major component of the extracellular matrix. Enzymatic removal of HA with hyaluronidase reduced nifedipine-sensitive whole-cell Ca 2+ currents, decreased Ca ...
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