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Interferon (IFN)-α and -β are important antiviral mediators. IFN-α is widely used for the treatment of chronic hepatitis B. In our previous studies, a subtype of woodchuck IFN-α (wIFN-α) was characterized and has been shown to be active in suppressing the replication of woodchuck hepatitis virus (WHV) in vitro and vivo. Here, we refined the analysis of the IFN-α/β system of the woodchuck and studied...
Interleukin 15 (IL-15) is a member of the four-helix bundle cytokine family and has T cell growth factor activity. IL-15 plays a unique role in both innate and adaptive immune cell homeostasis, particularly for the development of NK cells and CD8+memory cells. It may be useful for stimulation of specific immune responses in chronic viral infection such as hepatitis B virus infection.The woodchuck...
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