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Renal Cell Carcinoma
In article number 2203518, Ziqi Wang, Lei Wang, Hao Wang, Wanhai Xu, and co‐workers report a transformable extracellular matrix (ECM) deprivation system (EDS) that targets fibronectin for depriving the ECM of renal cell carcinoma (RCC). The cage‐like nanofibers formed by the EDS deprive the ECM of RCC cells, which efficaciously reverses anoikis resistance and ameliorates the RCC's...
Extracellular matrix (ECM) is crucial in various biological functions during tumor progression, including induction of anoikis resistance and cell adhesion‐mediated drug resistance (CAM‐DR). Fibronectin (FN) is a vital ECM component with direct regulatory effects on ECM‐mediated anoikis resistance and CAM‐DR, making it an attractive and innovative therapeutic target for depriving ECM in tumor tissue...
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