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Rationale
Quantitative ion‐pair (IP) high‐performance liquid chromatography/mass spectrometry (HPLC/MS) methods are employed to determine the complex impurity profiles of oligonucleotide therapeutics. While impurities that co‐elute with the main product are routinely monitored, the large number of early and late eluting impurities makes their individual measurements tedious and time‐consuming. An...