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Poly(D,L-lactic-co-glycolic acid) (PLGA) has been widely used as a biodegradable polymer in the fabrication of porous polymer scaffolds, but it is hydrolyzed into acidic by-products such as glycolic acid and lactic acid in the human body. Magnesium hydroxide nanoparticles (Mg-NPs) were incorporated into a PLGA scaffold in order to neutralize the acidic environment caused by the hydrolysis of PLGA,...
Small poly(D,L-lactide-co-glycolide) scaffold disks (2 mm in diameter) with a bimodal porous structure of 237.5±34.2 μm for large pores and 9.2±3.9 μm for micropores were prepared by gas-forming and controlled-precipitation methods. Chondrocyte-seeded scaffold disks were dispersed in an alginate solution containing culture media. The dispersion was transferred into a Teflon mold with a specific shape,...
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