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On page 1446, Junbai Li, Yang Yang, and co‐workers report that hemoglobin‐based capsules can be successfully fabricated through covalent layer‐by‐layer (LbL) assembly. Such assembled capsules are well controlled and adjusted to possess similar properties to those of living red blood cells, which enables the capsules to function as blood substitutes.
Hemoglobin‐based capsules for use as blood substitutes are successfully fabricated by covalent layer‐by‐layer assembly. Dialdehyde heparin (DHP) is used both as one of the wall components and a cross‐linker without employing other extraneous or toxic crosslinking agents. The biocompatibility of (Hb/DHP)6 microcapsules is evaluated through the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide)...
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