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The central event in molecular prion pathogenesis is the conformational change of the cellular prion protein (PrPC) to an abnormal prion protein (PrPSc), and the subsequent accumulation of PrPSc in infected human and animals. Recently, reports have shown that the exposure of scrapie-infected cells (ScN2a) to an anti-prion protein (PrP) antibody inhibited this conformational change and accumulation...
mAbs T1 and T2 were established by immunizing PrP gene ablated mice with recombinant MoPrP of residues 121–231. Both mAbs were cross‐reactive with PrP from hamster, sheep, cattle and deer. A linear epitope of mAb T1 was identified at residues 137–143 of MoPrP and buried in PrPC expressed on the cell surface. mAb T1 showed no inhibitory effect on accumulation of PrPSc in cultured scrapie‐infected neuroblastoma...
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