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The endogenous gas, hydrogen sulfide (H 2 S), plays an important role in regulating cardiovascular function and inflammation. It also contributes to the pathogenesis of insulin resistance and glucose metabolism [1–3]. Recently, it has been reported that large amounts of H 2 S are formed from L-cysteine by cystathionine gamma lyase (CSE) in fat tissues and that H 2 S reduces...
It has previously been reported that hydrogen sulfide (H 2 S) exerts both pro- and anti-apoptotic activity in different cultured cells [1–3]. However, the precise effect and mechanism(s) involved remain unclear. We have previously reported that the slow-releasing H 2 S donor, GYY4137 [4] (morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate) exerts anti-cancer activity both...
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