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DOI: 10.1002/jssc.202100066
The cover picture shows a schematic diagram of a liquid chromatography with tandem mass spectrometry method for analyzing microsomal and soluble epoxide hydrolase in rat heart, kidney, and liver S9 samples. Protein quantification was realized through targeted proteomics for the determination of trypsin‐specific surrogate peptides after digestion. A multiple reaction monitoring...
Epoxide hydrolases catalyze the hydrolysis of both exogenous and endogenous epoxides to the corresponding vicinal diols by adding water. Microsomal and soluble epoxide hydrolase are two main mammalian enzymes that have been intensely characterized. The purpose of this investigation was to develop and validate a proteomics assay allowing the simultaneous quantification of microsomal and soluble epoxide...
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