Search results for: Russell Ouellette

Items from 1 to 11 out of 11 results

article

MRI detection of brain gadolinium retention in multiple sclerosis: Magnetization transfer vs. T1‐weighted imaging

Carmen Cananau, Yngve Forslin, Åsa Bergendal, Henrik Sjöström, more

Journal of Neuroimaging > 33 > 2 > 247 - 255

Background and Purpose Evidence of brain gadolinium retention has affected gadolinium‐based contrast agent usage. It is, however, unclear to what extent macrocyclic agents are retained and whether their in vivo detection may necessitate nonconventional MRI. Magnetization transfer (MT) could prove suitable to detect gadolinium‐related signal changes since dechelated gadolinium ions bind to macromolecules...

article

Advanced MRI quantification of neuroinflammatory disorders

Russell Ouellette

Journal of Neuroscience Research > 100 > 7 > 1389 - 1394

article

Cortical and white matter lesion topology influences focal corpus callosum atrophy in multiple sclerosis

Michael Platten, Russell Ouellette, Elena Herranz, Valeria Barletta, more

Journal of Neuroimaging > 32 > 3 > 471 - 479

Background and Purpose Corpus callosum (CC) atrophy is a strong predictor of multiple sclerosis (MS) disability but the contributing pathological mechanisms remain uncertain. We aimed to apply advanced MRI to explore what drives the often nonuniform callosal atrophy. Methods Prospective brain 7 Tesla and 3 Tesla Human Connectom Scanner MRI were performed in 92 MS patients. White matter, leukocortical,...

article

Automatic deep learning multicontrast corpus callosum segmentation in multiple sclerosis

Irene Brusini, Michael Platten, Russell Ouellette, Fredrik Piehl, more

Journal of Neuroimaging > 32 > 3 > 459 - 470

Background and Purpose Corpus callosum (CC) atrophy is predictive of future disability in multiple sclerosis (MS). However, current segmentation methods are either labor‐ or computationally intensive. We therefore developed an automated deep learning‐based CC segmentation tool and hypothesized that its output would correlate with disability. Methods A cohort of 631 MS patients (449 females, baseline...

article

Deep Learning Corpus Callosum Segmentation as a Neurodegenerative Marker in Multiple Sclerosis

Michael Platten, Irene Brusini, Olle Andersson, Russell Ouellette, more

Journal of Neuroimaging > 31 > 3 > 493 - 500

Background and Purpose Corpus callosum atrophy is a sensitive biomarker of multiple sclerosis (MS) neurodegeneration but typically requires manual 2D or volumetric 3D‐based segmentations. We developed a supervised machine learning algorithm, DeepnCCA, for corpus callosum segmentation and relate callosal morphology to clinical disability using conventional MRI scans collected in clinical routine....

article

Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis

Gabriel Mangeat, Russell Ouellette, Maxime Wabartha, Benjamin De Leener, more

Journal of Neuroimaging > 30 > 5 > 674 - 682

BACKGROUND AND PURPOSE Hereditary diffuse leukoencephalopathy with spheroids (HDLS) and multiple sclerosis (MS) are demyelinating and neurodegenerative disorders that can be hard to distinguish clinically and radiologically. HDLS is a rare disorder compared to MS, which has led to occurrent misdiagnosis of HDLS as MS. That is problematic since their prognosis and treatment differ. Both disorders...

article

Validation of Rapid Magnetic Resonance Myelin Imaging in Multiple Sclerosis

Russell Ouellette, Gabriel Mangeat, Ildiko Polyak, Marcel Warntjes, more

Annals of Neurology > 87 > 5 > 710 - 724

Objective Magnetic resonance imaging (MRI) is essential for multiple sclerosis diagnostics but is conventionally not specific to demyelination. Myelin imaging is often hampered by long scanning times, complex postprocessing, or lack of clinical approval. This study aimed to assess the specificity, robustness, and clinical value of Rapid Estimation of Myelin for Diagnostic Imaging, a new myelin imaging...

article

MRI‐Based Manual versus Automated Corpus Callosum Volumetric Measurements in Multiple Sclerosis

Michael Platten, Juha Martola, Katharina Fink, Russell Ouellette, more

Journal of Neuroimaging > 30 > 2 > 198 - 204

BACKGROUND AND PURPOSE Corpus callosum atrophy is a neurodegenerative biomarker in multiple sclerosis (MS). Manual delineations are gold standard but subjective and labor intensive. Novel automated methods are promising but require validation. We aimed to compare the robustness of manual versus automatic corpus callosum segmentations based on FreeSurfer. METHODS Nine MS patients (6 females, age...

article

Changes in structural network are associated with cortical demyelination in early multiple sclerosis

Gabriel Mangeat, Atef Badji, Russell Ouellette, Constantina A. Treaba, more

Human Brain Mapping > 39 > 5 > 2133 - 2146

The aim of this study was to investigate the interplay between structural connectivity and cortical demyelination in early multiple sclerosis. About 27 multiple sclerosis patients and 18 age‐matched controls underwent two MRI scanning sessions. The first was done at 7T and involved acquiring quantitative T₁ and T₂* high‐resolution maps to estimate cortical myelination. The second was done on a Connectom...

chapter

Early axonal damage in normal appearing white matter in multiple sclerosis: Novel insights from multi-shell diffusion MRI

Silvia De Santis, Tobias Granberg, Russell Ouellette, Constantina A. Treaba, more

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) > 3024 - 3027

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Conventional diffusion-weighted MR imaging techniques provide limited specificity in disentangling disease-related microstructural alterations involving changes in both axonal density and myelination. By simultaneously probing multiple diffusion regimens, multi-shell diffusion MRI is capable of increasing specificity to different tissue sub-compartments and hence separate different contributions to...

article

Neuroinflammatory component of gray matter pathology in multiple sclerosis

Elena Herranz, Costanza Giannì, Céline Louapre, Constantina A. Treaba, more

Annals of Neurology > 80 > 5 > 776 - 790

Objective In multiple sclerosis (MS), using simultaneous magnetic resonance–positron emission tomography (MR‐PET) imaging with ¹¹C‐PBR28, we quantified expression of the 18kDa translocator protein (TSPO), a marker of activated microglia/macrophages, in cortex, cortical lesions, deep gray matter (GM), white matter (WM) lesions, and normal‐appearing WM (NAWM) to investigate the in vivo pathological...

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Search results for: Russell Ouellette

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