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Inosine 5ʹ‐monophosphate dehydrogenase (IMPDH) catalyzes a crucial step in the biosynthesis of DNA and RNA, and it has been exploited as a promising target for antimicrobial therapy. The present study discusses the development and synthesis of a series of sulfonyl‐α‐l‐amino acids coupled with the anisamide scaffold and evaluates their activities as anti‐Helicobacter pylori and IMPDH inhibitors. Twenty...
A new series of thiopyrimidine‐5‐carbonitrile derivatives were synthesized and the chemical identity of them was established on the basis of spectral methods. The antimicrobial properties of all derivatives were investigated against Gram‐positive and Gram‐negative bacteria as well as fungal strains. The results of the antimicrobial screening showed that compounds 4, 11, and 12 have a higher and broad...
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