Search results for: Olga Ciccarelli

Items from 1 to 20 out of 78 results

article

Grey Matter Atrophy and its Relationship with White Matter Lesions in Patients with Myelin Oligodendrocyte Glycoprotein Antibody‐associated Disease, Aquaporin‐4 Antibody‐Positive Neuromyelitis Optica Spectrum Disorder, and Multiple Sclerosis

Rosa Cortese, Marco Battaglini, Ferran Prados, Giordano Gentile, more

Annals of Neurology > 96 > 2 > 276 - 288

Objective To evaluate: (1) the distribution of gray matter (GM) atrophy in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder (AQP4+NMOSD), and relapsing–remitting multiple sclerosis (RRMS); and (2) the relationship between GM volumes and white matter lesions in various brain regions within each disease. ...

article

Cardiovascular risk factors in secondary progressive multiple sclerosis: A cross‐sectional analysis from the MS‐STAT2 randomized controlled trial

Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, more

European Journal of Neurology > 30 > 9 > 2769 - 2780

Background and purpose There is increasing evidence that cardiovascular risk (CVR) contributes to disability progression in multiple sclerosis (MS). CVR is particularly prevalent in secondary progressive MS (SPMS) and can be quantified through validated composite CVR scores. The aim was to examine the cross‐sectional relationships between excess modifiable CVR, whole and regional brain atrophy on...

article

The real incidence of biliary tract complications after adult liver transplantation: the role of the prospective routine use of cholangiography during post‐transplant follow‐up

Julie Navez, Samuele Iesari, Dhoha Kourta, Kente Baami‐Mariza, more

Transplant International > 34 > 2 > 245 - 258

Biliary tract complications (BTCs) still burden liver transplantation (LT). The wide reporting variability highlights the absence of systematic screening. From 2000 to 2009, simultaneous liver biopsy and direct biliary visualization were prospectively performed in 242 recipients at 3 and 6 months (n = 212, 87.6%) or earlier when indicated (n = 30, 12.4%). Median follow‐up was 148 (107–182) months...

article

Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

Bhavana S. Solanky, Ferran Prados, Carmen Tur, Marios C. Yiannakas, more

Journal of Magnetic Resonance Imaging > 52 > 5 > 1429 - 1438

Background Associations between brain total sodium concentration, disability, and disease progression have recently been reported in multiple sclerosis. However, such measures in spinal cord have not been reported. Purpose To measure total sodium concentration (TSC) alterations in the cervical spinal cord of people with relapsing–remitting multiple sclerosis (RRMS) and a control cohort using sodium...

article

Longitudinal Assessment of Multiple Sclerosis with the Brain‐Age Paradigm

James H. Cole, Joel Raffel, Tim Friede, Arman Eshaghi, more

Annals of Neurology > 88 > 1 > 93 - 105

Objective During the natural course of multiple sclerosis (MS), the brain is exposed to aging as well as disease effects. Brain aging can be modeled statistically; the so‐called “brain‐age” paradigm. Here, we evaluated whether brain‐predicted age difference (brain‐PAD) was sensitive to the presence of MS, clinical progression, and future outcomes. Methods In a longitudinal, multicenter sample of...

article

Two‐Stage Recipient Hepatectomy and Left Liver Transplantation to Minimize Risks in Adult‐to‐Adult Living Donor Liver Transplantation: New Concepts

Laurent Coubeau, Samuele Iesari, Olga Ciccarelli, Eliano Bonaccorsi‐Riani, more

Liver Transplantation > 26 > 3 > 450 - 455

article

A 30‐Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Karen K. Chung, Daniel Altmann, Frederik Barkhof, Katherine Miszkiel, more

Annals of Neurology > 87 > 1 > 63 - 74

Objective Clinical outcomes in multiple sclerosis (MS) are highly variable. We aim to determine the long‐term clinical outcomes in MS, and to identify early prognostic features of these outcomes. Methods One hundred thirty‐two people presenting with a clinically isolated syndrome were prospectively recruited between 1984 and 1987, and followed up clinically and radiologically 1, 5, 10, 14, 20,...

article

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Marcello Moccia, Ferran Prados, Massimo Filippi, Maria A. Rocca, more

Annals of Neurology > 86 > 5 > 704 - 713

Objective Spinal cord atrophy is a clinically relevant feature of multiple sclerosis (MS), but longitudinal assessments on magnetic resonance imaging using segmentation‐based methods suffer from measurement variability, especially in multicenter studies. We compared the generalized boundary shift integral (GBSI), a registration‐based method, with a standard segmentation‐based method. Methods Baseline...

article

Paediatric multiple sclerosis: a new era in diagnosis and treatment

Sophie Duignan, Wallace Brownlee, Evangeline Wassmer, Cheryl Hemingway, more

Developmental Medicine & Child Neurology > 61 > 9 > 1039 - 1049

Multiple sclerosis is a chronic immune‐mediated demyelinating disease of the central nervous system. The diagnosis of multiple sclerosis in children, as in adults, requires evidence of dissemination of inflammatory activity in more than one location in the central nervous system (dissemination in space) and recurrent disease over time (dissemination in time). The identification of myelin oligodendrocyte...

article

The Intention‐to‐Treat Effect of Bridging Treatments in the Setting of Milan Criteria–In Patients Waiting for Liver Transplantation

Quirino Lai, Alessandro Vitale, Samuele Iesari, Armin Finkenstedt, more

Liver Transplantation > 25 > 7 > 1023 - 1033

In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria (MC), the benefit of locoregional therapies (LRTs) in the context of liver transplantation (LT) is still debated. Initial biases in the selection between treated and untreated patients have yielded conflicting reported results. The study aimed to identify, using a competing risk analysis, risk factors for HCC‐dependent LT failure,...

article

SVM recursive feature elimination analyses of structural brain MRI predicts near-term relapses in patients with clinically isolated syndromes suggestive of multiple sclerosis

Viktor Wottschel, Declan T. Chard, Christian Enzinger, Massimo Filippi, more

NeuroImage: Clinical > 2019 > 24 > C

Machine learning classification is an attractive approach to automatically differentiate patients from healthy subjects, and to predict future disease outcomes. A clinically isolated syndrome (CIS) is often the first presentation of multiple sclerosis (MS), but it is difficult at onset to predict who will have a second relapse and hence convert to clinically definite MS. In this study, we thus aimed...

article

Retinal nerve fibre layer thinning is associated with worse visual outcome after optic neuritis in children with a relapsing demyelinating syndrome

Michael Eyre, Aasim Hameed, Sukhvir Wright, Wallace Brownlee, more

Developmental Medicine & Child Neurology > 60 > 12 > 1244 - 1250

Aim Optic neuritis may be monophasic or occur as part of a relapsing demyelinating syndrome (RDS), such as multiple sclerosis, aquaporin‐4 antibody (AQP4‐Ab) neuromyelitis optical spectrum disorder (NMOSD), or myelin oligodendrocyte glycoprotein antibody (MOG‐Ab)‐associated disease. The aims of this study were to test whether clinical, electrophysiological, and microstructural parameters differ in...

article

Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages

G. J. Melendez-Torres, Xavier Armoiry, Rachel Court, Jacoby Patterson, more

BMC Neurology > 2018 > 18 > 1 > 1-17

Background We systematically reviewed the comparative effectiveness of injectable beta-interferons (IFN-β) and glatiramer acetate (GA) on annualised relapse rate (ARR), progression and discontinuation due to adverse events (AEs) in RRMS, using evidence from within the drugs’ recommended dosages. Methods We updated prior comprehensive reviews, checked references of included studies, contacted experts...

article

Myelin oligodendrocyte glycoprotein and aquaporin‐4 antibodies are highly specific in children with acquired demyelinating syndromes

Sophie Duignan, Sukhvir Wright, Tom Rossor, John Cazabon, more

Developmental Medicine & Child Neurology > 60 > 9 > 958 - 962

Aim Our objectives were to evaluate the utility of measuring myelin oligodendrocyte glycoprotein (MOG) and aquaporin‐4 (AQP4) antibodies (Ab) in clinical practice and describe their associated neurological phenotypes in children. Method Between 2012 and 2017, 371 children with suspected acquired demyelinating syndromes (ADS) seen in three tertiary centres were tested for MOG‐Ab and AQP4‐Ab. Medical...

article

‘Leukodystrophy‐like’ phenotype in children with myelin oligodendrocyte glycoprotein antibody‐associated disease

Yael Hacohen, Thomas Rossor, Kshitij Mankad, Wk ‘Kling’ Chong, more

Developmental Medicine & Child Neurology > 60 > 4 > 417 - 423

Aim To review the demographics and clinical and paraclinical parameters of children with myelin oligodendrocyte glycoprotein (MOG) antibody‐associated relapsing disease. Method In this UK‐based, multicentre study, 31 children with MOG antibody‐associated relapsing disease were studied retrospectively. Results Of the 31 children studied, 14 presented with acute disseminated encephalomyelitis (ADEM);...

article

Deep gray matter volume loss drives disability worsening in multiple sclerosis

Arman Eshaghi, Ferran Prados, Wallace J. Brownlee, Daniel R. Altmann, more

Annals of Neurology > 83 > 2 > 210 - 222

Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. Methods We analyzed 3,604 brain high‐resolution T1‐weighted magnetic resonance imaging scans from 1,417 participants: 1,214 MS patients (253 clinically isolated syndrome [CIS], 708...

article

Prediction of a multiple sclerosis diagnosis in patients with clinically isolated syndrome using the 2016 MAGNIMS and 2010 McDonald criteria: a retrospective study

Massimo Filippi, Paolo Preziosa, Alessandro Meani, Olga Ciccarelli, more

The Lancet Neurology > 2018 > 17 > 2 > 133-142

In 2016, the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) network proposed modifications to the MRI criteria to define dissemination in space (DIS) and time (DIT) for the diagnosis of multiple sclerosis in patients with clinically isolated syndrome (CIS). Changes to the DIS definition included removal of the distinction between symptomatic and asymptomatic lesions, increasing the number...

article

Performance of five research-domain automated WM lesion segmentation methods in a multi-center MS study

Alexandra de Sitter, Martijn D. Steenwijk, Aurélie Ruet, Adriaan Versteeg, more

NeuroImage > 2017 > 163 > C > 106-114

In vivoidentification of white matter lesions plays a key-role in evaluation of patients with multiple sclerosis (MS). Automated lesion segmentation methods have been developed to substitute manual outlining, but evidence of their performance in multi-center investigations is lacking. In this work, five research-domain automated segmentation methods were evaluated using a multi-center MS dataset.70...

article

Endocrinopathies in paediatric-onset Aquaporin 4 (AQP4) antibody neuromyelitis optica spectrum disorder

Yael Hacohen, Silvia Messina, Hoong-Wei Gan, Sukhvir Wright, more

European Journal of Paediatric Neurology > 2017 > 21 > S1 > e7

article

Treatment responsive relapsing MOG-Ab associated demyelination

Yael Hacohen, Yu Yi Wong, Christian Lechner, Sukhvir Wright, more

European Journal of Paediatric Neurology > 2017 > 21 > S1 > e154

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INFONA - science communication portal

Search results for: Olga Ciccarelli

Grey Matter Atrophy and its Relationship with White Matter Lesions in Patients with Myelin Oligodendrocyte Glycoprotein Antibody‐associated Disease, Aquaporin‐4 Antibody‐Positive Neuromyelitis Optica Spectrum Disorder, and Multiple Sclerosis

Cardiovascular risk factors in secondary progressive multiple sclerosis: A cross‐sectional analysis from the MS‐STAT2 randomized controlled trial

The real incidence of biliary tract complications after adult liver transplantation: the role of the prospective routine use of cholangiography during post‐transplant follow‐up

Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

Longitudinal Assessment of Multiple Sclerosis with the Brain‐Age Paradigm

Two‐Stage Recipient Hepatectomy and Left Liver Transplantation to Minimize Risks in Adult‐to‐Adult Living Donor Liver Transplantation: New Concepts

A 30‐Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Paediatric multiple sclerosis: a new era in diagnosis and treatment

The Intention‐to‐Treat Effect of Bridging Treatments in the Setting of Milan Criteria–In Patients Waiting for Liver Transplantation

SVM recursive feature elimination analyses of structural brain MRI predicts near-term relapses in patients with clinically isolated syndromes suggestive of multiple sclerosis

Retinal nerve fibre layer thinning is associated with worse visual outcome after optic neuritis in children with a relapsing demyelinating syndrome

Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages

Myelin oligodendrocyte glycoprotein and aquaporin‐4 antibodies are highly specific in children with acquired demyelinating syndromes

‘Leukodystrophy‐like’ phenotype in children with myelin oligodendrocyte glycoprotein antibody‐associated disease

Deep gray matter volume loss drives disability worsening in multiple sclerosis

Prediction of a multiple sclerosis diagnosis in patients with clinically isolated syndrome using the 2016 MAGNIMS and 2010 McDonald criteria: a retrospective study

Performance of five research-domain automated WM lesion segmentation methods in a multi-center MS study

Endocrinopathies in paediatric-onset Aquaporin 4 (AQP4) antibody neuromyelitis optica spectrum disorder

Treatment responsive relapsing MOG-Ab associated demyelination

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