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Gross morphology of a neonatal brain dissected from Yap‐cKO by crossing Yapflox/flox and Nestin‐Cre. While it appears to be normal, intermediate progenitor cells and upper‐layer projection neurons in the cerebral cortex are decreased. From: YAP maintains the production of intermediate progenitor cells and upper‐layer projection neurons in the mouse cerebral cortex; Yi‐Ching Su, Tzu‐Heng Hung, Tzu‐Fang...
Background
The Hippo pathway is conserved through evolution and plays critical roles in development, tissue homeostasis and tumorigenesis. Yes‐associated protein (YAP) is a transcriptional coactivator downstream of the Hippo pathway. Previous studies have demonstrated that activation of YAP promotes proliferation in the developing brain. Whether YAP is required for the production of neural progenitor...
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