Search results for: Chiara Dalla Man

Items from 1 to 20 out of 26 results

article

Modelling and assessment of glucose‐lactate kinetics in youth with overweight, obesity and metabolic dysfunction‐associated steatotic liver disease: A pilot study

Jacopo Bonet, Delaney Fox, Rafaela Nelson, Michael B. Nelson, more

Diabetes, Obesity and Metabolism > 26 > 8 > 3207 - 3212

Aim In this study, we investigated glucose and lactate kinetics during a 75 g oral glucose tolerance test (OGTT) in 23 overweight and obese adolescents and assessed putative differences among participants with and without metabolic dysfunction‐associated steatotic liver disease (MASLD). Methods We enrolled 23 young people (six girls) with obesity [body mass index 33 (29‐37)]. Glucose‐lactate kinetics...

article

Interleaved trinuclear MRS for single‐session investigation of carbohydrate and lipid metabolism in human liver at 7T

Simone Poli, Ahmed F. Emara, Naomi F. Lange, Edona Ballabani, more

NMR in Biomedicine > 37 > 8 > n/a - n/a

The liver plays a central role in metabolic homeostasis, as exemplified by a variety of clinical disorders with hepatic and systemic metabolic disarrays. Of particular interest are the complex interactions between lipid and carbohydrate metabolism in highly prevalent conditions such as obesity, diabetes, and fatty liver disease. Limited accessibility and the need for invasive procedures challenge...

article

Four weeks SGLT2 inhibition improves beta cell function and glucose tolerance without affecting muscle free fatty acid or glucose uptake in subjects with type 2 diabetes

Jens Hohwü Voigt, Katrine M. Lauritsen, Steen Bønløkke Pedersen, Troels K. Hansen, more

Basic & Clinical Pharmacology & Toxicology > 134 > 5 > 643 - 656

Aims Sodium glucose co‐transporter‐2 (SGLT2) inhibition lowers glucose levels independently of insulin, leading to reduced insulin secretion and increased lipolysis, resulting in elevated circulating free fatty acids (FFAs). While SGLT2 inhibition improves tissue insulin sensitivity, the increase in circulating FFAs could reduce insulin sensitivity in skeletal muscle and the liver. We aimed to investigate...

article

Clinical evaluation of a decision support system for glucose infusion in hypoglycaemic clamp experiments

Jacopo Pavan, David Herzig, Afrodity Tripyla, Chiara Dalla Man, more

Diabetes, Obesity and Metabolism > 25 > 12 > 3709 - 3715

Aim To provide a preliminary evaluation of the accuracy and safety of Gluclas decision support system suggestions in a hypoglycaemic clamp study. Methods This analysis was performed using data from 32 participants (four groups with different glucose‐insulin regulation: post Roux‐en‐Y gastric bypass with and without postprandial hypoglycaemia syndrome, postsleeve gastrectomy and non‐operated controls)...

article

Improved postprandial glucose metabolism in type 2 diabetes by the dual glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 in comparison with liraglutide

Michele Schiavon, Roberto Visentin, Britta Göbel, Michela Riz, more

Diabetes, Obesity and Metabolism > 23 > 8 > 1795 - 1805

Aim To gain further insights into the efficacy of SAR425899, a dual glucagon‐like peptide‐1/glucagon receptor agonist, by providing direct comparison with the glucagon‐like peptide‐1 receptor agonist, liraglutide, in terms of key outcomes of glucose metabolism. Research Design and Methods Seventy overweight to obese subjects with type 2 diabetes (T2D) were randomized to receive once‐daily subcutaneous...

article

Limitations of the fasting proinsulin to insulin ratio as a measure of β‐cell health in people with and without impaired glucose tolerance

Aoife M. Egan, Marcello C. Laurenti, Maria Daniela Hurtado Andrade, Chiara Dalla Man, more

European Journal of Clinical Investigation > 51 > 6 > n/a - n/a

Background The fasting proinsulin to insulin ratio is elevated in people with type 2 diabetes and has been suggested as a marker of β‐cell health. However, its utility in discriminating between individuals with varying degrees of β‐cell dysfunction is unclear. Proinsulin has a very different half‐life to insulin and unlike insulin does not undergo hepatic extraction prior to reaching the systemic...

article

Dual glucagon‐like peptide‐1 receptor/glucagon receptor agonist SAR425899 improves beta‐cell function in type 2 diabetes

Roberto Visentin, Michele Schiavon, Britta Göbel, Michela Riz, more

Diabetes, Obesity and Metabolism > 22 > 4 > 640 - 647

Aim To evaluate the change in insulin sensitivity, β‐cell function and glucose absorption after 28 days of treatment with high and low doses of SAR425899, a novel dual glucagon‐like peptide‐1 receptor/glucagon receptor agonist, versus placebo. Materials and Methods Thirty‐six overweight to obese subjects with type 2 diabetes were randomized to receive daily subcutaneous administrations of low‐dose...

article

Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids

Steven Hamley, Danielle Kloosterman, Tamara Duthie, Chiara Dalla Man, more

Diabetologia > 2019 > 62 > 12 > 2310-2324

Aims/hypothesis This study aimed to examine the metabolic health of young apparently healthy non-obese adults to better understand mechanisms of hyperinsulinaemia. Methods Non-obese (BMI < 30 kg/m²) adults aged 18–35 years (N = 254) underwent a stable isotope-labelled OGTT. Insulin sensitivity, glucose effectiveness and beta cell function were determined using oral minimal models. Individuals...

article

Intranasal oxytocin fails to acutely improve glucose metabolism in obese men

Swantje Brede, Sebastian Fehr, Chiara Dalla‐Man, Claudio Cobelli, more

Diabetes, Obesity and Metabolism > 21 > 2 > 424 - 428

The hypothalamic neuropeptide oxytocin not only modulates psychosocial function, but also contributes to metabolic regulation. We have recently shown that intranasal oxytocin acutely improves beta‐cell responsivity and glucose tolerance in normal‐weight men. In the present experiment, we investigated the acute glucoregulatory impact of oxytocin in obese men with impaired insulin sensitivity. Fifteen...

article

Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans

Jingyi Qian, Chiara Dalla Man, Christopher J. Morris, Claudio Cobelli, more

Diabetes, Obesity and Metabolism > 20 > 10 > 2481 - 2485

Glucose tolerance is lower at night and higher in the morning. Shift workers, who often eat at night and experience circadian misalignment (i.e. misalignment between the central circadian pacemaker and the environmental/behavioural cycles), have an increased risk of type 2 diabetes. To determine the separate and relative impacts of the circadian system, behavioural/environmental cycles, and their...

article

Performance of individually measured vs population‐based C‐peptide kinetics to assess β‐cell function in the presence and absence of acute insulin resistance

Ron T. Varghese, Chiara Dalla Man, Marcello C. Laurenti, Francesca Piccinini, more

Diabetes, Obesity and Metabolism > 20 > 3 > 549 - 555

Aims To compare the performance of population‐based kinetics with that of directly measured C‐peptide kinetics when used to calculate β‐cell responsivity indices, and to study people with and without acute insulin resistance to ensure that population‐based kinetics apply to all conditions where β‐cell function is measured. Methods Somatostatin was used to inhibit endogenous insulin secretion in...

article

Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass

Jonathan Q. Purnell, Geoffrey S. Johnson, Abdus S. Wahed, Chiara Dalla Man, more

Diabetologia > 2018 > 61 > 5 > 1142-1154

Aims/hypothesis In this prospective case–control study we tested the hypothesis that, while long-term improvements in insulin sensitivity (S_I) accompanying weight loss after Roux-en-Y gastric bypass (RYGB) would be similar in obese individuals with and without type 2 diabetes mellitus, stimulated-islet-cell insulin responses would differ, increasing (recovering) in those with diabetes but decreasing...

article

Glucose metabolism during rotational shift-work in healthcare workers

Anu Sharma, Marcello C. Laurenti, Chiara Dalla Man, Ron T. Varghese, more

Diabetologia > 2017 > 60 > 8 > 1483-1490

Aims/hypothesis Shift-work is associated with circadian rhythm disruption and an increased risk of obesity and type 2 diabetes. We sought to determine the effect of rotational shift-work on glucose metabolism in humans. Methods We studied 12 otherwise healthy nurses performing rotational shift-work using a randomised crossover study design. On each occasion, participants underwent an isotope-labelled...

article

One-Day Bayesian Cloning of Type 1 Diabetes Subjects: Toward a Single-Day UVA/Padova Type 1 Diabetes Simulator

Roberto Visentin, Chiara Dalla Man, Claudio Cobelli

IEEE Transactions on Biomedical Engineering > 2016 > 63 > 11 > 2416 - 2424

Objective: The UVA/Padova Type 1 Diabetes (T1DM) Simulator has been shown to be representative of a T1DM population observed in a clinical trial, but has not yet been identified on T1DM data. Moreover, the current version of the simulator is “single meal” while making it “single-day centric,” i.e., by describing intraday variability, would be a step forward to create more realistic in silico scenarios...

article

A Model for the Estimation of Hepatic Insulin Extraction After a Meal

Francesca Piccinini, Chiara Dalla Man, Adrian Vella, Claudio Cobelli

IEEE Transactions on Biomedical Engineering > 2016 > 63 > 9 > 1925 - 1932

Goal: Quantitative assessment of hepatic insulin extraction (HE) after an oral glucose challenge, e.g., a meal, is important to understand the regulation of carbohydrate metabolism. The aim of the current study is to develop a model of system for estimating HE. Methods: Nine different models, of increasing complexity, were tested on data of 204 normal subjects, who underwent a mixed meal tolerance...

article

Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial

Andrew L. Siebel, Si Khiang Trinh, Melissa F. Formosa, Piyushkumar A. Mundra, more

Metabolism > 2016 > 65 > 6 > 904-914

High-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I) can modulate glucose metabolism through multiple mechanisms. This study determined the effects of a novel bromodomain and extra-terminal (BET) inhibitor (RVX-208) and putative apoA-I inducer on lipid species contained within HDL (HDL lipidome) and glucose metabolism.Twenty unmedicated males with prediabetes received 100mg b.i.d. RVX-208...

article

Long-Term Outcomes of Biliopancreatic Diversion on Glycemic Control, Insulin Sensitivity and Beta Cell Function

Ana Carolina Junqueira Vasques, José Carlos Pareja, Maria de Oliveira, Fernanda Satake Novaes, more

Obesity Surgery > 2016 > 26 > 11 > 2572-2580

Background We aimed to assess the long-term outcomes of biliopancreatic diversion (BPD) surgery on glycemic control, insulin sensitivity (IS), and beta cell function using complementary oral and intravenous dynamic tests. Methods A total of 57 women were divided into three groups: 19 lean, 18 obese (both groups with normal glucose tolerance (NGT)), and 20 obese with type 2 diabetes who underwent...

chapter

Incorporation of inhaled insulin into the FDA accepted University of Virginia/Padova Type 1 Diabetes Simulator

Roberto Visentin, Thomas Klabunde, Marshall Grant, Chiara Dalla Man, more

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) > 3250 - 3253

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

The University of Virginia/Padova Type 1 Diabetes (T1DM) Simulator has been extensively used in artificial pancreas research mostly for testing and design of control algorithms. However, it also offers the possibility of testing new insulin analogs and alternative routes of delivery given that subcutaneous insulin administration present significant delays & variability. Inhaled insulin appears...

article

Epicardial and Pericardial Fat in Type 2 Diabetes: Favourable Effects of Biliopancreatic Diversion

Ana Carolina Junqueira Vasques, José Carlos Pareja, José Roberto Mattos Souza, Ademar Yamanaka, more

Obesity Surgery > 2015 > 25 > 3 > 477-485

Purpose Ectopic fat is often identified in obese subjects who are susceptible to the development of type 2 diabetes mellitus (T2DM). The ectopic fat favours the decrease in insulin sensitivity (IS) and adiponectin levels. We aimed to evaluate the effect of biliopancreatic diversion (BPD) on the accumulation of ectopic fat, adiponectin levels and IS in obese with T2DM. Materials and Methods...

article

Advancing Our Understanding of the Glucose System via Modeling: A Perspective

Claudio Cobelli, Chiara Dalla Man, Morten Gram Pedersen, Alessandra Bertoldo, more

IEEE Transactions on Biomedical Engineering > 2014 > 61 > 5 > 1577 - 1592

The glucose story begins with Claude Bernard's discovery of glycogen and milieu interieur, continued with Banting's and Best's discovery of insulin and with Rudolf Schoenheimer's paradigm of dynamic body constituents. Tracers and compartmental models allowed moving to the first quantitative pictures of the system and stimulated important developments in terms of modeling methodology. Three classes...

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INFONA - science communication portal

Search results for: Chiara Dalla Man

Modelling and assessment of glucose‐lactate kinetics in youth with overweight, obesity and metabolic dysfunction‐associated steatotic liver disease: A pilot study

Interleaved trinuclear MRS for single‐session investigation of carbohydrate and lipid metabolism in human liver at 7T

Four weeks SGLT2 inhibition improves beta cell function and glucose tolerance without affecting muscle free fatty acid or glucose uptake in subjects with type 2 diabetes

Clinical evaluation of a decision support system for glucose infusion in hypoglycaemic clamp experiments

Improved postprandial glucose metabolism in type 2 diabetes by the dual glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 in comparison with liraglutide

Limitations of the fasting proinsulin to insulin ratio as a measure of β‐cell health in people with and without impaired glucose tolerance

Dual glucagon‐like peptide‐1 receptor/glucagon receptor agonist SAR425899 improves beta‐cell function in type 2 diabetes

Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids

Intranasal oxytocin fails to acutely improve glucose metabolism in obese men

Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans

Performance of individually measured vs population‐based C‐peptide kinetics to assess β‐cell function in the presence and absence of acute insulin resistance

Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass

Glucose metabolism during rotational shift-work in healthcare workers

One-Day Bayesian Cloning of Type 1 Diabetes Subjects: Toward a Single-Day UVA/Padova Type 1 Diabetes Simulator

A Model for the Estimation of Hepatic Insulin Extraction After a Meal

Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial

Long-Term Outcomes of Biliopancreatic Diversion on Glycemic Control, Insulin Sensitivity and Beta Cell Function

Incorporation of inhaled insulin into the FDA accepted University of Virginia/Padova Type 1 Diabetes Simulator

Epicardial and Pericardial Fat in Type 2 Diabetes: Favourable Effects of Biliopancreatic Diversion

Advancing Our Understanding of the Glucose System via Modeling: A Perspective

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