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Aim: Delayed graft revascularization impedes the success of human islet transplantation. This study utilized rotational co‐culture of insulin secreting β‐cells with human umbilical vein endothelial cells (HUVECs) and a peroxisome proliferator‐activated receptor gamma (PPAR‐γ) agonist to promote insulin and vascular endothelial growth factor (VEGF) secretory function.
Methods: Clonal BRIN‐BD11 (D11)...
Aims/hypothesis Loss of the trophic support provided by surrounding non-endocrine pancreatic cell populations underlies the decline in beta cell mass and insulin secretory function observed in human islets following isolation and culture. This study sought to determine whether restoration of regulatory influences mediated by ductal epithelial cells promotes sustained beta cell function in vitro. ...
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