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Checkpoint inhibitors have emerged as beneficial therapies in many different types of malignancy. The most common toxicities of checkpoint inhibitors are immune‐related adverse events (irAEs). As clinical experience with these agents increases, more irAEs have been described. We report a case of scleroderma‐like skin changes induced by checkpoint inhibitor therapy. A 61‐year‐old man was treated with...
Background
Reliable nuclear immunohistochemical stains for sebaceous neoplasms have not been readily available. Positive nuclear staining has been reported for GATA3 and factor XIIIa (AC‐1A1). We sought to determine the diagnostic utility of these nuclear stains by comparing their staining pattern to adipophilin, a consistently positive cytoplasmic stain.
Methods
Cases with the diagnosis of sebaceous...
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