Search results for: Hongyan Pei

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article

Astragalin improves cognitive disorder in Alzheimer's disease: Based on network pharmacology and molecular docking simulation

Rui Du, Hongyan Pei, Zhongmei He, Jin Wang, more

CNS Neuroscience & Therapeutics > 30 > 8 > n/a - n/a

We investigate the mechanism of action of astragalin (AST) in the treatment of Alzheimer's disease (AD). Network pharmacology was conducted to analyze the relationships among AST, AD, and neuroinflammation, The APP/PS1 transgenic mice with AD were used in the experiments; to be specific, the influence of AST on the behavior of mice was analyzed by Morris water maze and eight‐arm radial maze tests,...

article

Gastrodin improves nerve cell injury and behaviors of depressed mice through Caspase‐3‐mediated apoptosis

Hongyan Pei, Heping Shen, Jinhao Bi, Zhongmei He, more

CNS Neuroscience & Therapeutics > 30 > 3 > n/a - n/a

Aim We investigated the effects and target of gastrodin (GAS) for treating depression through network pharmacology combined with experimentation. Methods The therapeutic target and signal of GAS for depression were analyzed by network pharmacology. Depression in mice was mimicked with a chronic unpredictable mouse stress (CUMS) model. Through open field, elevated plus maze, forced swimming, and...

article

HIPK2 mediates M1 polarization of microglial cells via STAT3: A new mechanism of depression‐related neuroinflammation

Chenyang Han, Hongyan Pei, Yongjia Sheng, Jin Wang, more

Journal of Cellular Physiology > 239 > 3 > n/a - n/a

This study aimed to investigate the role of protein kinase HIPK2 in depression and its associated mechanism. The chronic unpredictable mild stress (CUSM) model was constructed to simulate mice with depression to detect the mouse behaviors. Moreover, by using mouse microglial cells BV2 as the model. After conditional knockdown of HIPK2, the depressive behavior disorder of mice was improved, meanwhile,...

article

Palmatine attenuates LPS‐induced neuroinflammation through the PI3K/Akt/NF‐κB pathway

Jianning Zeng, Hongyan Pei, Hong Wu, Weijia Chen, more

Journal of Biochemical and Molecular Toxicology > 38 > 1 > n/a - n/a

To investigate the key molecular mechanisms of palmatine for the treatment of neuroinflammation through modulation of a pathway using molecular docking, molecular dynamics (MD) simulation combined with network pharmacology, and animal experiments. Five alkaloid components were obtained from the traditional Chinese medicine Huangteng through literature mining. Molecular docking and MD simulation with...

article

Paeoniflorin suppresses neuronal ferroptosis to improve the cognitive behaviors in Alzheimer's disease mice

Liping Zhai, Hongyan Pei, Heping Shen, Yi Yang, more

Phytotherapy Research > 37 > 10 > 4791 - 4800

Aim of this research was to examine the impact of paeoniflorin (Pae) in suppressing the occurrence of ferroptosis in individuals with Alzheimer's disease (AD). The study utilized APP/PS1 mice with AD as the experimental subjects. Following the administration of Pae, the cognitive behaviors of mice were evaluated and the key indexes of ferroptosis were measured, as well as levels of oxidative stress...

article

Double‐negative T cells regulate the progression of liver fibrosis through Th9 cells differentiation

Chenyang Han, Hongyan Pei, Yongjia Sheng, Jin Wang, more

Liver International > 43 > 7 > 1604 - 1613

Our previous study found that double negative T cells (DNTs) could promote the NLRP3 activation through high expression of TNF‐α, thereby leading to hepatic fibrosis progression. We focused on investigating the role and mechanism of DNTs in regulating the Th9 cells differentiation in liver fibrosis. In our results, among patients with liver fibrosis, the proportions of peripheral blood DNTs and Th9...

article

Network pharmacology and molecular docking analysis on the mechanism of Cordyceps militaris polysaccharide regulating immunity through TLR4/TNF‐α pathwayss

Hongyan Pei, Zhongmei He, Weijia Chen, Yan Zhao, more

Journal of Biochemical and Molecular Toxicology > 37 > 6 > n/a - n/a

The role of polysaccharide components in the immune system, especially immunomodulatory effects, has received increasing attention. In this context, in this study, network pharmacology was adopted to explore the hypothesis of a multitarget mechanism for immune modulation by Chrysalis polysaccharides. A total of 174 common targets were screened by network pharmacology, with the main ones being TNF,...

article

Evaluating the effect of ginsenoside Rg1 on CPF‐induced brain injury in mice via PI3k/AKT pathway

Silu Liu, Hongyan Pei, Weijia Chen, Xiaoying Zhu, more

Journal of Biochemical and Molecular Toxicology > 37 > 5 > n/a - n/a

Organophosphorus pesticides (OPs) have long been used extensively on agricultural land and can lead to significant improvements in crop yields. Due to occupational exposure, humans are exposed to pesticides through dermal contact, inhalation, and ingestion. The effects of OPs on the organism are currently studied for their effects on livers, kidneys, hearts, blood indicators, neurotoxicity, and teratogenic,...

article

Aurantiamide suppresses the activation of NLRP3 inflammasome to improve the cognitive function and central inflammation in mice with Alzheimer's disease

Heping Shen, Hongyan Pei, Liping Zhai, Qiaobing Guan, more

CNS Neuroscience & Therapeutics > 29 > 4 > 1075 - 1085

Aim This study was aimed at exploring the mechanism by which aurantiamide (Aur) targeted NLRP3 to suppress microglial cell polarization. Methods The 7‐month‐old APP/PS1 mice and C57BL/6 mice were applied to be the study objects, and Aur was administered intragastrically to APP/PS1 mice at 10 mg/kg and 20 mg/kg. The changes in the neurocognitive function of mice were measured by Morris Water Maze...

article

Front Cover Picture: Strecker Reactions of Formaldehyde with TMSCN, Catalyzed by TBAF and Formic Acid: N‐Monocyanomethylation of Primary Amines (Adv. Synth. Catal. 1/2023)

Yunting Liu, Jing Zhang, Jianyu Zhang, Hongyan Pei, more

Advanced Synthesis & Catalysis > 365 > 1 > 1 - 1

The front cover picture illustrates the Strecker reaction of formaldehyde, primary amines and TMSCN. HCOOH and TBAF were used as cocatalysts and the TMSCN was used to work as both the cyanide source and protecting reagent. As a result, the side reactions were suppressed efficiently and a broad range of aromatic and aliphatic amines were efficiently monocyanomethylated. This work is dedicated to Shenyang...

article

Strecker Reactions of Formaldehyde with TMSCN, Catalyzed by TBAF and Formic Acid: N‐Monocyanomethylation of Primary Amines

Yunting Liu, Jing Zhang, Jianyu Zhang, Hongyan Pei, more

Advanced Synthesis & Catalysis > 365 > 1 > 2 - 7

A set of conditions for the Strecker reaction of formaldehyde, amines, and TMSCN that affords three‐component coupling adducts as the major products is reported. HCOOH and TBAF are used as cocatalysts and the TMSCN functions as both cyanide source and protecting reagent for amines. As a result, the side reactions were suppressed efficiently and a broad range of aromatic and aliphatic amines were mono‐cyanomethylated...

article

Aurantiamide promotes M2 polarization of microglial cells to improve the cognitive ability of mice with Alzheimer's disease

Heping Shen, Zhongmei He, Hongyan Pei, Liping Zhai, more

Phytotherapy Research > 37 > 1 > 101 - 110

This work aimed to investigate the effect of aurantiamide (Aur) in promoting the M2 polarization of microglial cells to improve the cognitive ability of mice with Alzheimer's disease (AD). The M2 polarization of BV2 cells was induced by interleukin‐4 (IL‐4) treatment.Aur promoted the M2 polarization of BV2 cells, and up‐regulated the expression of CD206 and SOCS3. In the meantime, it increased TGF‐β1,...

article

Palmatine ameliorates LPS‐induced HT‐22 cells and mouse models of depression by regulating apoptosis and oxidative stress

Hongyan Pei, Jianning Zeng, Zhongmei He, Ying Zong, more

Journal of Biochemical and Molecular Toxicology > 37 > 1 > n/a - n/a

Depression is one of the most common neuropsychiatric disorders that is characterized by low mood, lack of motivation, slow thinking, and recurrent suicidal thoughts. The mechanism of action of palmatine in depression has been rarely reported and remains unclear. The present study examined the neuroprotective effects of palmatine on lipopolysaccharide (LPS)‐induced oxidative stress, apoptosis, and...

article

Network pharmacology and molecular docking integrated strategy to investigate the pharmacological mechanism of palmatine in Alzheimer's disease

Hongyan Pei, Jianning Zeng, Weijia Chen, Zhongmei He, more

Journal of Biochemical and Molecular Toxicology > 36 > 11 > n/a - n/a

Objective The key molecular mechanism of palmatine in the treatment of Alzheimer's disease (AD) was investigated in this article. Methods Network pharmacology techniques constructed drug‐target‐disease relationship networks and predictive pathways of action. At the cellular level, lipopolysaccharide (LPS) was used to induce Raw 264.7 cells to establish an inflammation model, and interleukin (IL)‐1β,...

chapter

A multi-object black hole gravitational search algorithm for day-ahead reactive optimization in distribution network

Hongyan Pei, Yunhua Li, Keyan Liu

2016 IEEE Chinese Guidance, Navigation and Control Conference (CGNCC) > 901 - 906

2016 IEEE Chinese Guidance, Navigation and Control Conference (CGNCC)

Heuristic search algorithms, based on their advantages in multi-objective and multi-dimensions optimization, have been widely utilized in reactive power optimization problem. In this paper, we propose a new heuristic search algorithm, named black hole gravitational search algorithm (BHGSA), which is combined black hole algorithm (BHA) with gravitational search algorithm (GSA), to solve day-ahead reactive...

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