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In the current study, we compared the in vitro potency of a unique form of gonadotropin-releasing hormone (GnRH) present in the brain of the guinea pig (gpGnRH) with that of mammalian GnRH (mGnRH) as well as their binding affinities to the GnRH receptor. In gpGnRH, the highly conserved histidine in position 2 (His 2 ) and leucine in position 7 (Leu 7 ) are substituted by tyrosine and...
In this study we compared the biological activity of a unique form of gonadotropin-releasing hormone (GnRH) in the brain of the guinea pig (gpGnRH) with mammalian GnRH (mGnRH). In gpGnRH, the highly conserved histidine in position 2 (His 2 ) and leucine in position 7 (Leu 7 ) are substituted by tyrosine and valine, respectively. The gpGnRH was less potent than mGnRH in stimulating...
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