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Background and objectiveWith the worldwide emergence of highly drug‐resistant tuberculosis (TB), novel agents that have direct antimycobacterial effects or that enhance host immunity are urgently needed. Curcumin is a polyphenol responsible for the bright yellow‐orange colour of turmeric, a spice derived from the root of the perennial herb Curcuma longa. Curcumin is a potent inducer of apoptosis—an...
Background Macrophages are the primary effector cells responsible for killing Mycobacterium tuberculosis ( MTB ) through various mechanisms, including apoptosis. However, MTB can evade host immunity to create a favorable environment for intracellular replication. MTB -infected human macrophages produce interleukin-32 (IL-32). IL-32 is a pro-inflammatory...
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