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Among the different connexin proteins in the heart, connexin 43 (Cx43) dominates in ventricular cardiomyocytes. Whereas Cx43 is well known to form both hemichannels and gap junctions, Cx43 is also present in other regions of the cell, in addition to the plasma membrane, including mitochondria. The activity of Cx43 is regulated by its level of expression and/or posttranslational modifications. The...
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