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Allergen exposure chambers (AECs) can be used for controlled exposure to allergenic and non‐allergenic airborne particles in an enclosed environment, in order to (i) characterize the pathological features of respiratory diseases and (ii) contribute to and accelerate the clinical development of pharmacological treatments and allergen immunotherapy for allergic disease of the respiratory tract (such...
Background
Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical symptoms and vary in their responses to treatments.
Methods
We applied k‐means clustering algorithm of twelve objective laboratory tests among 351 asthmatic children enrolled in the Taiwanese Consortium of Childhood Asthma Study (TCCAS). We constructed gene...
Background
Proton pump inhibitors (PPIs) have been known to induce type I hypersensitivity reactions. However, severe delayed‐type hypersensitivity reactions (DHR) induced by PPI, such as Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug rash with eosinophilia and systemic symptoms (DRESS), are rarely reported. We conducted a study of a large series of PPI‐related DHR, followed...
There is growing evidence that multiple genes and air pollutants are associated with asthma. By identifying the effect of air pollution on the general population, the effects of air pollution on childhood asthma can be better understood. We conducted the Taiwan Children Health Study (TCHS) to investigate the influence of gene–air pollution interactions on childhood asthma. Complete monitoring data...
To cite this article: An S, Ma D, Wei JF, Yang X, Yang HW, Yang H, Xu X, He S, Lai R. A novel allergen Tab y 1 with inhibitory activity of platelet aggregation from salivary glands of horseflies. Allergy 2011; 66: 1420–1427.
AbstractBackground: Horsefly sting causes allergic reactions in human body. However, our knowledge on horsefly allergens remains poor.Objectives: To identify the novel horsefly...
To cite this article: He S, Li T, Chen H, Ma W, Yao Q, Yang H, Wang H, Wang F, Zhao C, Yang P. CD14+ cell–derived IL‐29 modulates proinflammatory cytokine production in patients with allergic airway inflammation. Allergy 2011; 66: 238–246.
AbstractBackground: Interleukin (IL)‐29 is a newly described cytokine that has anti‐viral activity, induces tumor cell death and regulates immune function. Whether...
To cite this article: Ma D, Li Y, Dong J, An S, Wang Y, Liu C, Yang X, Yang H, Xu X, Lin D, Lai R. Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanus yao. Allergy 2011; 66: 101–109.
AbstractBackground: Horsefly bite can cause allergic reactions in humans. There is no information about allergenic horsefly proteins.Objectives: The current work...
To cite this article: He S, Zhang H, Chen H, Yang H, Huang T, Chen Y, Lin J, Wang F, Chen X, Li T‐L, Yang P. Expression and release of IL‐29 by mast cells and modulation of mast cell behavior by IL‐29. Allergy 2010; 65: 1234–1241.
AbstractBackground: The role of interleukin (IL)‐29 in innate immunity has been recognized recently, and it is regarded as a potent bioactive molecule. However, little...
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