Search results for: Heejae Kim

Items from 1 to 18 out of 18 results

article

Tunable modulation of antibody‐antigen interaction by protease cleavage of protein M

Heejae Kim, Andrew Gaynor, Wilfred Chen

Biotechnology and Bioengineering > 116 > 11 > 2834 - 2842

While immunoglobulins find ubiquitous use in biotechnology as static binders, recent developments have created proantibodies that enable orthogonal switch‐like behavior to antibody function. Previously, peptides with low binding affinity have been genetically fused to antibodies, to proteolytically control binding function by blocking the antigen‐binding site. However, development of these artificial...

article

Kopplung von hoch‐ und niederfrequenten Schwingungsmoden in organisch‐anorganischen Perowskiten

Maksim Grechko, Simon A. Bretschneider, Laura Vietze, Heejae Kim, more

Angewandte Chemie > 130 > 41 > 13845 - 13849

Das Zusammenspiel elektronischer und nuklearer Freiheitsgrade in halbleitenden, organisch‐anorganischen Hybrid‐Perowskiten bestimmt viele ihrer grundlegenden photophysikalischen Eigenschaften. Photoinduzierte Ladungsträger polarisieren lokal das Gitter. Analog zur Schwingung des Kristallgitters kann die lokale Polarisation durch ein Quasipartikel beschrieben werden, das Polaron. Es vereint infolge...

article

Vibrational Coupling between Organic and Inorganic Sublattices of Hybrid Perovskites

Maksim Grechko, Simon A. Bretschneider, Laura Vietze, Heejae Kim, more

Angewandte Chemie International Edition > 57 > 41 > 13657 - 13661

The interplay of electronic and nuclear degrees of freedom in semiconductor hybrid organic–inorganic perovskites determines many of their fundamental photophysical properties. For instance, charge carriers are dressed with phonons, that is, form polarons, and combination modes composed of strongly mixed localized vibrations and delocalized phonons can provide pathways for electronic energy relaxation...

article

41‐5: Invited Paper: Quantum Dot Conversion Layers Through Inkjet Printing

Ernest Lee, Ravi Tangirala, Austin Smith, Amanda Carpenter, more

SID Symposium Digest of Technical Papers > 49 > 1 > 525 - 527

Quantum dot color conversion layers have the potential to greatly improve the efficiency and color performance of displays including and beyond liquid crystal displays. To fully realize these improvements, the quantum dots must be deposited and patterned at high resolution. One promising method for achieving this is through inkjet printing. In this paper we report on the fabrication and characterization...

article

Complexity in Acid–Base Titrations: Multimer Formation Between Phosphoric Acids and Imines

Christian Malm, Heejae Kim, Manfred Wagner, Johannes Hunger

Chemistry – A European Journal > 23 > 45 > 10853 - 10860

Solutions of Brønsted acids with bases in aprotic solvents are not only common model systems to study the fundamentals of proton transfer pathways but are also highly relevant to Brønsted acid catalysis. Despite their importance the light nature of the proton makes characterization of acid–base aggregates challenging. Here, we track such acid–base interactions over a broad range of relative compositions...

article

Bio-orthogonal conjugation and enzymatically triggered release of proteins within multi-layered hydrogels

Chen Guo, Heejae Kim, Elisa M. Ovadia, Christine M. Mourafetis, more

Acta Biomaterialia > 2017 > 56 > C > 80-90

Hydrogels are facile architectures for the controlled presentation of proteins with far-reaching applications, from fundamental biological studies in three-dimensional culture to new regenerative medicine and therapeutic delivery strategies. Here, we demonstrate a versatile approach for spatially-defined presentation of engineered proteins within hydrogels through i) immobilization using bio-orthogonal...

article

67‐2: Invited Paper: Ambient Processing of Quantum Dot Photoresist for Emissive Displays

Ernie Lee, Shihai Kan, Charlie Hotz, Jeff Yurek, more

SID Symposium Digest of Technical Papers > 48 > 1 > 984 - 987

Moving the light conversion by quantum dots (QDs) from the backlight to the front of the LCD has the potential to further improve both the overall efficiency and color gamut of the display. In order to accomplish this change of architecture, the QDs have to be patterned at the sub‐pixel pitch of the display. This requires the QDs to be integrated into a photoresist at high concentration in order to...

chapter

IsV2C: An Integrated Road Traffic-Network-Cloud Simulator for V2C Connected Car Services

Heejae Kim, Jiyong Han, Seong-Hwan Kim, Jisoo Choi, more

2017 IEEE International Conference on Services Computing (SCC) > 434 - 441

2017 IEEE International Conference on Services Computing (SCC)

The recent growth of connected car technology encourages IT and vehicle organizations to develop advanced vehicle-to-cloud (V2C) services such as driving assistance, infotainment, and vehicle maintenance. However, since their performances highly depend on the resource configuration and regional characteristics, it is almost impossible to examine the service feasibility in every candidate region by...

article

Joint Selection for Cooperative Spectrum Sensing in Wireless Sensor Networks

Yuyang Peng, Fawaz Al-Hazemi, Heejae Kim, Chan-Hyun Youn

IEEE Sensors Journal > 2016 > 16 > 22 > 7837 - 7838

A joint selected strategy is proposed for wireless sensor networks to address the energy consumption problem in this letter. The proposed strategy saves energy by selecting the sensor and modulation constellation size. Results from simulations show that the proposed strategy obtains significant energy reduction compared with the existing strategy under the same environment.

article

A non-chromatographic protein purification strategy using Src 3 homology domains as generalized capture domains

Heejae Kim, Wilfred Chen

Journal of Biotechnology > 2016 > 234 > C > 27-34

Protein purification using inverse phase transition of elastin-like polypeptide (ELP) domains is a useful alternative to chromatography. Genetic fusions of ELP domains to various proteins have the ability to reversibly transition between soluble monomers and micron-sized aggregates and this has been used to selectively purify many ELP fusions. Affinity domains can enhance this technology by using...

article

Hofmeister‐Effekte unter der Lupe: Die direkte Anion‐Amid‐Bindung ist schwächer als die Kation‐Amid‐Bindung

Vasileios Balos, Heejae Kim, Mischa Bonn, Johannes Hunger

Angewandte Chemie > 128 > 28 > 8257 - 8261

Trotz vermehrter Hinweise auf direkte Wechselwirkungen als Ursache für die Destabilisierung von Proteinen durch Ionen blieb die Frage nach der Stärke der Bindung von Anionen zu Proteinen im Vergleich zu jener von Kationen offen. Die Rotation eines Modellamids wurde nun als Maß für die Wechselwirkung verschiedener Anionen mit der Amidgruppe verwendet. Die Untersuchungen zeigen, dass Protein‐stabilisierende...

article

Dissecting Hofmeister Effects: Direct Anion–Amide Interactions Are Weaker than Cation–Amide Binding

Vasileios Balos, Heejae Kim, Mischa Bonn, Johannes Hunger

Angewandte Chemie International Edition > 55 > 28 > 8125 - 8128

Whereas there is increasing evidence for ion‐induced protein destabilization through direct ion–protein interactions, the strength of the binding of anions to proteins relative to cation–protein binding has remained elusive. In this work, the rotational mobility of a model amide in aqueous solution was used as a reporter for the interactions of different anions with the amide group. Protein‐stabilizing...

article

Design and Optimization for Energy-Efficient Cooperative MIMO Transmission in Ad Hoc Networks

Yuyang Peng, Fawaz Al-Hazemi, Heejae Kim, Chan-Hyun Youn

IEEE Transactions on Vehicular Technology > 2017 > 66 > 1 > 710 - 719

The need to reduce energy consumption for lowering operating costs has pushed energy efficiency to become one of the major issues of current research in the field of ad hoc networks. In this paper, a new cooperative strategy of multiple-input–multiple-output (MIMO) based on spatial modulation (SM) for the randomly distributed nodes (CMIMO-SMR) in an ad hoc network is proposed to optimize the whole...

article

Bioengineering strategies to generate artificial protein complexes

Heejae Kim, Ka‐Hei Siu, Maryam Raeeszadeh‐Sarmazdeh, Qing Sun, more

Biotechnology and Bioengineering > 112 > 8 > 1495 - 1505

For many applications, increasing synergy between distinct proteins through organization is important for the specificity, regulation, and overall reaction efficiency. Although there are many examples of protein complexes in nature, a generalized method to create these complexes remains elusive. Many conventional techniques such as random chemical conjugation, physical adsorption onto surfaces, and...

article

Biomolecular scaffolds for enhanced signaling and catalytic efficiency

Rebecca Chen, Qi Chen, Heejae Kim, Ka-Hei Siu, more

Current Opinion in Biotechnology > 2014 > 28 > Complete > 59-68

Proteins inherently are not designed to be standalone entities. Whether it is a multi-step biochemical reaction or a signaling event that triggers several other cascading events, proteins are naturally designed to function cohesively. Several natural systems have been developed through evolution to co-localize the functional proteins of the same pathway in order to ensure efficient communication of...

article

Biologically Assembled Nanobiocatalysts

Heejae Kim, Qing Sun, Fang Liu, Shen-Long Tsai, more

Topics in Catalysis > 2012 > 55 > 16-18 > 1138-1145

The use of nanostructures for enzyme immobilization is an attractive method to increase the overall activity and stability. Self-assembly of enzyme nanostructures has also been shown to provide similar beneficial effects with improved control at the molecular level. In this review paper, we highlighted the recent success in the use of biological assembly methods in creating highly active nanobiocatalysts.

article

Large Area Two-Dimensional B Cell Arrays for Sensing and Cell-Sorting Applications

Heejae Kim, Junsang Doh, Darrell J. Irvine, Robert E. Cohen, more

Biomacromolecules > 2004 > 5 > 3 > 822 - 827

article

Three dimensional FEM simulation for spinning of non-circular fibers

Heejae Kim, Kwansoo Chung, Jae Ryoun Youn

Fibers and Polymers > 2000 > 1 > 1 > 37-44

A finite element method is employed for a flow analysis of the melt spinning process of a non-circular fiber, a PET(polyethylene terephthalate) filament. The flow field is divided into two regions of die channel and spin-line. A two dimensional analysis is used for the flow within the die channel and a three dimensional analysis for the flow along the spin-line. The Newtonian fluid is assumed for...

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