ObjectivesHypothermia has a well‐established neuroprotective effect and offers a foundation for combination therapy for brain ischemia. The authors evaluated the effect of combination therapy with insulin‐like growth factor‐1 (IGF‐1) and hypothermia on brain structure and function in the setting of global brain ischemia and reperfusion in rats.
MethodsMale Sprague‐Dawley rats were randomly assigned...
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