Search results for: Fu-Yu Chueh

Items from 1 to 8 out of 8 results

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Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation

Shahrooz Vahedi, Fu-Yu Chueh, Bala Chandran, Chao-Lan Yu

BMC Cancer > 2015 > 15 > 1 > 1-14

Background Many cancer cells exhibit reduced mitochondrial respiration as part of metabolic reprogramming to support tumor growth. Mitochondrial localization of several protein tyrosine kinases is linked to this characteristic metabolic shift in solid tumors, but remains largely unknown in blood cancer. Lymphocyte-specific protein tyrosine kinase (Lck) is a key T-cell kinase and widely implicated...

article

Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells

Fu-Yu Chueh, Chao-Lan Yu

Biochemical and Biophysical Research Communications > 2012 > 426 > 2 > 242-246

Signal transducer and activator of transcription (STAT) proteins are key signaling molecules in response to cytokines and in regulating T cell biology. However, there are contradicting reports on whether STAT is involved in T-cell antigen receptor (TCR) signaling. To better define the role of STAT in TCR signaling, we activated the CD4/CD8-associated Lck kinase by co-crosslinking TCR and CD4/CD8 co-receptors...

article

Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene

Srividya Venkitachalam, Fu-Yu Chueh, Chao-Lan Yu

Biochemical and Biophysical Research Communications > 2012 > 417 > 3 > 1058-1062

LIM domain only protein 2 (Lmo2) is a transcription factor that plays a critical role in the development of T-acute lymphoblastic leukemia (T-ALL). A previous report established a link between Lmo2 expression and the nuclear presence of oncogenic Janus kinase 2 (JAK2), a non-receptor protein tyrosine kinase. The oncogenic JAK2 kinase phosphorylates histone H3 on Tyr 41 that leads to the relief of...

article

Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription

Fu-Yu Chueh, King-Fu Leong, Robert J. Cronk, Srividya Venkitachalam, more

Cellular Signalling > 2011 > 23 > 7 > 1170-1178

STAT (signal transducer and activator of transcription) proteins play a critical role in cellular response to a wide variety of cytokines and growth factors by regulating specific nuclear genes. STAT-dependent gene transcription can be finely tuned through the association with co-factors in the nucleus. We showed previously that STAT5 (including 5a and 5b) specifically interacts with a mitochondrial...

article

Metabolic response to endotoxin in vivo in the conscious mouse: role of interleukin-6

Andrea Tweedell, Kimberly X. Mulligan, Josie E. Martel, Fu-Yu Chueh, more

Metabolism > 2011 > 60 > 1 > 92-98

Inflammation and insulin resistance are characteristics of endotoxemia. Although the role of interleukin (IL)-6 in insulin-resistant states has been characterized, little is known of its role in the metabolic response to inflammation. To study the role of IL-6, conscious chronically catheterized mice were used. Five days before being studied, catheters were implanted in the carotid artery and jugular...

article

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells

Fu-Yu Chueh, King-Fu Leong, Chao-Lan Yu

Biochemical and Biophysical Research Communications > 2010 > 402 > 4 > 778-783

Signal transducers and activators of transcription (STATs) were first identified as key signaling molecules in response to cytokines. Constitutive STAT activation also has been widely implicated in oncogenesis. We analyzed STAT5-associated proteins in a leukemic T cell line LSTRA, which exhibits constitutive tyrosine phosphorylation and activation of STAT5. A cellular protein was found to specifically...

article

Advantages of dynamic “closed loop” stable isotope flux phenotyping over static “open loop” clamps in detecting silent genetic and dietary phenotypes

Bhavapriya Vaitheesvaran, Fu-Yu Chueh, Jun Xu, Chuck Trujillo, more

Metabolomics > 2010 > 6 > 2 > 180-190

In vivo insulin sensitivity can be assessed using “open loop” clamp or “closed loop” methods. Open loop clamp methods are static, and fix plasma glucose independently from plasma insulin. Closed loop methods are dynamic, and assess glucose disposal in response to a stable isotope labeled glucose tolerance test. Using PPARα^−/− mice, open and closed loop assessments of insulin sensitivity/glucose disposal...

article

The hypothermic effects of dl-tetrahydropalmatine in rats

Mao-Tsun Lin, Fu-Yu Chueh, Ming-Tsuen Hsieh

Neuroscience Letters > 2001 > 315 > 1-2 > 53-56

Systemic administration of dl-tetrahydropalmatine (THP; 10-50 mg.kg ^- ¹ intraperitoneally) produced a proportional decrease in both colonic temperature and release of hypothalamic serotonin (5-hydroxytryptamine (5-HT)) in rats at room temperature. The hypothermia was brought about by cutaneous vasodilation and decreased metabolism. The THP- induced hypothermia was significantly attenuated...

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