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Immunoglobulin heavy chain (Igh) locus rearrangements are controlled in part by an ∼30kb complex 3′ regulatory region located 3′ of Cα: this region contains several enhancers. We report here the comparison of the genomic sequences of the 3′ regulatory region and further downstream sequences from mouse, rat, human and chimpanzee. Only short segments of homology were detected in the 3′ regulatory region,...
Abstract. Rationale: Although the behavioral, subjective, and physiological effects of oral cocaine have been investigated, its reinforcing effects have not been demonstrated. Objective: The primary aims of this study were to examine the reinforcing effects of oral cocaine and determine whether such effects can be influenced by manipulating behavioral requirements following drug ingestion. Methods:...
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