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Background The alpha-adrenergic agonist phenylephrine is often used to treat hypotension during anesthesia. In clinical situations, low blood pressure may require prompt intervention by intravenous bolus or infusion. Differences in responsiveness to phenylephrine treatment are commonly observed in clinical practice. Candidate gene studies indicate genetic variants may contribute to this variable response...
This paper presents preliminary results from a pilot study for automated management of blood loss during surgery. The paper describes our approach in developing mathematical models for the cardiovascular system including blood loss and use of colloids for resuscitation. Further, adaptive models are synthesized and used for designing appropriate control algorithms. These algorithms are further integrated...
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