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Quantum dots (QDs) have shown great potential for biomedical use in a broad range including diagnostic agents. However, the regulatory mechanism of dermal toxicity is poorly understood. In this study, we investigated how QDs‐induced apoptosis is regulated in human keratinocytes. We also examined the effect of carboxylic acid‐coated QDs (QD 565 and QD 655) on reactive oxygen species (ROS) production...
Although the two anti-diabetic drugs, dipeptidyl peptidase-4 inhibitors (DPP4is) and glucagon-like peptide-1 (GLP-1) receptor agonists (GLP1RAs), have distinct effects on the dynamics of circulating incretins, little is known of the difference in their consequences on morphology and function of pancreatic islets. We examined these in a mouse model of β cell injury/regeneration. The model mice were...
To investigate the involvement of autophagy in folliculogenesis and its correlation with apoptosis.Animal model–based study.University medical center.Twenty-one day-old female Sprague-Dawley rats.Ovaries obtained from established immature rat models primed with pregnant mare serum gonadotropin (PMSG) were used for the induction of follicular development and atresia. Granulosa cells isolated from developing...
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