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To elucidate the role of bradykinin in the complex pathophysiology of bacterial meningitis we investigated the effect of the bradykinin B 2 receptor antagonist Hoe140, icatibant (d-Arg[Hyp 3 -Thi 5 -d-Tic 7 -Oic 8 ]-bradykinin), on pathophysiological alterations in experimental pneumococcal meningitis. Untreated rats injected intracisternally (i.c.) with heat-killed...
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