Search results for: Kazumasa Komura

Items from 1 to 20 out of 26 results

article

Real world evidence of enfortumab vedotin in patients with advanced urothelial cancer: A multicenter observational study

Wataru Fukuokaya, Yuhei Koike, Yuji Yata, Kazumasa Komura, more

International Journal of Urology > 31 > 4 > 342 - 347

Objectives To explore the characteristics of patients and assess the effectiveness of enfortumab vedotin (EV) in those with treatment‐resistant advanced urothelial cancer in a real‐world setting. Patients and Methods A multicenter observational study was conducted on 103 evaluable patients with advanced urothelial cancer who received EV. Outcomes were assessed by radiographic response, progression‐free...

article

The fluctuation of skin perfusion pressure in hemodialysis patients treated with LDL apheresis therapy: A comparison of LDL adsorption and double filtration plasmapheresis

Hitoshi Yoshimura, Yuki Yoshikawa, Yuki Noguchi, Teruhiko Totani, more

Journal of Clinical Apheresis > 38 > 4 > 362 - 367

Background There have been a number of reports suggesting that LDL apheresis, including LDL adsorption and double filtration plasmapheresis (DFPP), can be applied for the treatment of lower extremity peripheral arterial disease (PAD) in hemodialysis patients, whereas there is no definitive recommendation for the use of LDL apheresis. Study Design The change of skin perfusion pressure (SPP) during...

article

Hypoxia regulates tumour characteristic RNA modifications in ovarian cancers

Yuya Monoe, Shunsuke Miyamoto, Kentaro Jingushi, Masaya Tanimoto, more

The FEBS Journal > 290 > 8 > 2085 - 2096

Analysis of ovarian cancer tissue and normal ovarian tissue revealed 31 RNA modifications with significant differences observed in cancer tissue compared with normal tissue. Moreover, we found Im and chm5U as characteristic RNA modifications in advanced and platinum‐resistant ovarian cancers, respectively. Considering that these differences in RNA modifications may be due to the intra‐tumour microenvironment,...

article

Re‐challenging chemotherapy after pembrolizumab in platinum‐refractory urothelial carcinoma

Taizo Uchimoto, Tatsuo Fukushima, Kazumasa Komura, Wataru Fukuokaya, more

BJU International > 131 > 4 > 477 - 485

Objectives To assess the real‐world clinical benefit of re‐challenging chemotherapy after pembrolizumab in patients with metastatic urothelial carcinoma (mUC), as there have been several reports suggesting that programmed cell death protein‐1/programmed death‐ligand 1inhibitors can restore platinum sensitivity. Patients and Methods Of 236 patients treated with pembrolizumab, we excluded 45 patients...

article

Robot‐assisted modified radical hysterectomy with removal of lymphatic vessel using indocyanine green: A new method

Tomohito Tanaka, Ruri Nishie, Shoko Ueda, Sousuke Hashida, more

The International Journal of Medical Robotics and Computer Assisted Surgery > 18 > 6 > n/a - n/a

Background The sentinel lymph node (SLN) procedures using indocyanine green (ICG) have recently been performed worldwide. The aim of this study was to emphasise the safety of robot‐assisted modified radical hysterectomy (RAMRH) with removal of the lymphatic vessels (RLV) using ICG in endometrial cancer according to a single surgeon's experience. Methods Robot‐assisted modified radical hysterectomy...

article

Bladder cancer prospective cohort study on high‐risk non‐muscle invasive bladder cancer after photodynamic diagnosis‐assisted transurethral resection of the bladder tumor (BRIGHT study)

Keita Kobayashi, Hideyasu Matsuyama, Taketo Kawai, Atsushi Ikeda, more

International Journal of Urology > 29 > 7 > 632 - 638

Objectives Transurethral resection of bladder tumor with photodynamic diagnosis has been reported to result in lower residual tumor and intravesical recurrence rates in non‐muscle invasive bladder cancer. We aimed to evaluate the usefulness of photodynamic diagnosis‐transurethral resection of bladder tumor combined with oral 5‐aminolevulinic acid hydrochloride for high‐risk non‐muscle invasive bladder...

article

Risk stratification for the prediction of overall survival could assist treatment decision‐making at diagnosis of castration‐resistant prostate cancer: a multicentre collaborative study in Japan

Taizo Uchimoto, Kazumasa Komura, Wataru Fukuokaya, Takahiro Kimura, more

BJU International > 127 > 2 > 212 - 221

Objectives To assess whether a new risk stratification system according to predictors for overall survival (OS) at the diagnosis of metastatic castration‐resistant prostate cancer (mCRPC) could determine treatment outcomes and assist in treatment decision‐making. Patients and Methods Two independent clinical cohorts of patients, treated with androgen signalling inhibitors (ASIs: abiraterone and...

article

Prognostic impact of C-reactive protein-albumin ratio for the lethality in castration-resistant prostate cancer

Taizo Uchimoto, Kazumasa Komura, Yuya Fujiwara, Kenkichi Saito, more

Medical Oncology > 2020 > 37 > 1 > 1-9

This study aimed to assess the clinical value of C-reactive protein-albumin ratio (CAR) at the initiation of first-line treatment for castration-resistant prostate cancer (CRPC). We identified 221 CRPC patients treated with either androgen-signaling inhibitors (ASIs: abiraterone and enzalutamide) or docetaxel as the first-line treatment. The value of CAR was evaluated at the initiation of first-line...

article

The CANLPH Score, an Integrative Model of Systemic Inflammation and Nutrition Status (SINS), Predicts Clinical Outcomes After Surgery in Renal Cell Carcinoma: Data From a Multicenter Cohort in Japan

Kazumasa Komura, Takeshi Hashimoto, Takuya Tsujino, Ryu Muraoka, more

Annals of Surgical Oncology > 2019 > 26 > 9 > 2994-3004

Background A myriad of studies have demonstrated the clinical association of systemic inflammatory and nutrition status (SINS) including C-reactive protein/albumin ratio (CAR), the neutrophil/lymphocyte ratio (NLR), and the platelet/hemoglobin ratio (PHR). This study aimed to investigate the predictive value of the score integrating these variables (CANLPH) in patients with renal cell carcinoma (RCC)...

article

Current treatment strategies for advanced prostate cancer

Kazumasa Komura, Christopher J Sweeney, Teruo Inamoto, Naokazu Ibuki, more

International Journal of Urology > 25 > 3 > 220 - 231

During the past decade, treatment strategies for patients with advanced prostate cancer involving stage IV (T4N0M0, N1M0 or M1) hormone‐sensitive prostate cancer and recurrent prostate cancer after treatment with curative intent, as well as castration‐resistant prostate cancer, have extensively evolved with the introduction and approval of several new agents including sipuleucel‐T, radium‐223, abiraterone,...

article

Can bladder preservation therapy come to the center stage?

Teruo Inamoto, Naokazu Ibuki, Kazumasa Komura, Hiroshi Juri, more

International Journal of Urology > 25 > 2 > 134 - 140

Decision‐making in urological cancer care requires a multidisciplinary approach for refinement, but its impact on urothelial carcinoma of the bladder has not been fully addressed for the past three decades, except for the latest immunological checkpoint inhibitor approved by the U.S. Food and Drug Administration for metastatic muscle‐invasive bladder cancer that is resistant to platinum‐based chemotherapy...

article

Spontaneous rupture of the urinary bladder (SRUB): Recovery from cardiopulmonary arrest

Kohei Taniguchi, Ryo Iida, Koshi Ota, Masahiko Nitta, more

The American Journal of Emergency Medicine > 2017 > 35 > 10 > 1584.e5-1584.e7

Spontaneous rupture of the urinary bladder (SRUB) is rare and results in a lethal condition, i.e., pan peritonitis. However, early and accurate diagnosis of SRUB is very difficult. A 54-year-old woman was transported to our hospital with suspicion of pan peritonitis after spontaneous return of circulation with pulseless electrical activity. Laboratory investigation seemed to indicate acute renal failure...

article

Preoperative Measurement of the Modified Glasgow Prognostic Score Predicts Patient Survival in Non-Metastatic Renal Cell Carcinoma Prior to Nephrectomy

Takuya Tsujino, Kazumasa Komura, Tomohisa Matsunaga, Yuki Yoshikawa, more

Annals of Surgical Oncology > 2017 > 24 > 9 > 2787-2793

Purpose The modified Glasgow Prognostic Score (mGPS) by measurement of serum C-reactive protein and albumin levels has been shown to provide prognostic value in various cancer types. The purpose of this study was to evaluate whether preoperative assessment of the mGPS predicts patient survival outcome in renal cell carcinoma (RCC). Materials and Methods Clinicopathological and follow-up data in...

article

MP88-19 MIR-145 MODULATES WARBURG EFFECT BY TARGETING KLF4/PTB1/PKMS AXIS IN BLADDER CANCER CELLS.

Koichiro Minami, Kohei Taniguchi, Teruo Inamoto, Kiyoshi Takahara, more

The Journal of Urology > 2017 > 197 > 4(S) > e1181-e1182

article

MP28-14 DECREASED EXPRESSION OF MALE SPECIFIC HISTONE DEMETHYLASE “KDM5D” IS PROGNOSTIC FOR DEVELOPMENT OF CASTRATION-RESISTANT PROSTATE CANCER

Kazumasa Komura, Seong Ho Jeong, Haruhito Azuma, Gwo-Shu Lee, more

The Journal of Urology > 2017 > 197 > 4(S) > e343-e344

article

MP7-02 THE SYSTEMIC INFLAMMATION-BASED GLASGOW PROGNOSTIC SCORE AS A POWERFUL PROGNOSTIC FACTOR IN PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA

Teruo Inamoto, Shigeru Sakano, Tomoaki Takai, Kazumasa Komura, more

The Journal of Urology > 2015 > 193 > 4 Supplement > e64

article

Incidence of urethral stricture after bipolar transurethral resection of the prostate using TURis: results from a randomised trial

Kazumasa Komura, Teruo Inamoto, Tomoaki Takai, Taizo Uchimoto, more

BJU International > 115 > 4 > 644 - 652

ObjectivesTo assess whether bipolar transurethral resection of the prostate (B‐TURP) using the TURis^® system has a similar level of efficacy and safety to that of the traditional monopolar transurethral resection of the prostate (M‐TURP), and to evaluate the impact of the TURis system on postoperative urethral stricture rates over a 36‐month follow‐up period. Patients and MethodsA total of 136 patients...

article

E74-like factor inhibition induces reacquisition of hormone sensitiveness decreasing period circadian protein homolog 1 expression in prostate cancer cells

Kohei Koyama, Kiyoshi Takahara, Teruo Inamoto, Naokazu Ibuki, more

Prostate International > 2015 > 3 > 1 > 16-21

Initiating as an androgen-dependent adenocarcinoma, prostate cancer (PCa) gradually progresses to a castrate-resistant disease following androgen deprivation therapy with a propensity to metastasize.In order to resolve the mechanism of castrate-resistant PCa, we performed a cDNA-microarray assay of two PCa cell lines, LNCaP (androgen dependent) and C4-2 (androgen independent). Among them, we focused...

article

Novel Bladder Preservation Therapy with Osaka Medical College Regimen

Haruhito Azuma, Teruo Inamoto, Kiyoshi Takahara, Hayahito Nomi, more

The Journal of Urology > 2015 > 193 > 2 > 443-450

We investigated the effect of balloon occluded arterial infusion of an anticancer agent (cisplatin/gemcitabine), used concomitantly with hemodialysis, which delivers an extremely high concentration of anticancer agent to the tumor site without systemic adverse effects, along with concurrent radiation (referred to as the Osaka Medical College regimen) in patients with advanced bladder cancer.A total...

article

Could Transurethral Resection of the Prostate Using the TURis System Take Over Conventional Monopolar Transurethral Resection of the Prostate? A Randomized Controlled Trial and Midterm Results

Kazumasa Komura, Teruo Inamoto, Tomoaki Takai, Taizo Uchimoto, more

Urology > 2014 > 84 > 2 > 405-411

To assess whether bipolar transurethral resection of the prostate using the TURis (Olympus, Tokyo, Japan) system demonstrates comparable efficacy and safety reporting 36 months of follow-up findings.The trial was registered at University hospital Medical Information Network Clinical Trials Registry in Japan (trial number UMIN 000010801). Patients were randomly selected to undergo transurethral resection...

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INFONA - science communication portal

Search results for: Kazumasa Komura

Real world evidence of enfortumab vedotin in patients with advanced urothelial cancer: A multicenter observational study

The fluctuation of skin perfusion pressure in hemodialysis patients treated with LDL apheresis therapy: A comparison of LDL adsorption and double filtration plasmapheresis

Hypoxia regulates tumour characteristic RNA modifications in ovarian cancers

Re‐challenging chemotherapy after pembrolizumab in platinum‐refractory urothelial carcinoma

Robot‐assisted modified radical hysterectomy with removal of lymphatic vessel using indocyanine green: A new method

Bladder cancer prospective cohort study on high‐risk non‐muscle invasive bladder cancer after photodynamic diagnosis‐assisted transurethral resection of the bladder tumor (BRIGHT study)

Risk stratification for the prediction of overall survival could assist treatment decision‐making at diagnosis of castration‐resistant prostate cancer: a multicentre collaborative study in Japan

Prognostic impact of C-reactive protein-albumin ratio for the lethality in castration-resistant prostate cancer

The CANLPH Score, an Integrative Model of Systemic Inflammation and Nutrition Status (SINS), Predicts Clinical Outcomes After Surgery in Renal Cell Carcinoma: Data From a Multicenter Cohort in Japan

Current treatment strategies for advanced prostate cancer

Can bladder preservation therapy come to the center stage?

Spontaneous rupture of the urinary bladder (SRUB): Recovery from cardiopulmonary arrest

Preoperative Measurement of the Modified Glasgow Prognostic Score Predicts Patient Survival in Non-Metastatic Renal Cell Carcinoma Prior to Nephrectomy

MP88-19 MIR-145 MODULATES WARBURG EFFECT BY TARGETING KLF4/PTB1/PKMS AXIS IN BLADDER CANCER CELLS.

MP28-14 DECREASED EXPRESSION OF MALE SPECIFIC HISTONE DEMETHYLASE “KDM5D” IS PROGNOSTIC FOR DEVELOPMENT OF CASTRATION-RESISTANT PROSTATE CANCER

MP7-02 THE SYSTEMIC INFLAMMATION-BASED GLASGOW PROGNOSTIC SCORE AS A POWERFUL PROGNOSTIC FACTOR IN PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA

Incidence of urethral stricture after bipolar transurethral resection of the prostate using TURis: results from a randomised trial

E74-like factor inhibition induces reacquisition of hormone sensitiveness decreasing period circadian protein homolog 1 expression in prostate cancer cells

Novel Bladder Preservation Therapy with Osaka Medical College Regimen

Could Transurethral Resection of the Prostate Using the TURis System Take Over Conventional Monopolar Transurethral Resection of the Prostate? A Randomized Controlled Trial and Midterm Results

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