Search results for: Attila Balog

Items from 1 to 15 out of 15 results

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Association of Combined Anti‐Ro52/TRIM21 and Anti‐Ro60/SSA Antibodies With Increased Sjögren Disease Severity Through Interferon Pathway Activation

Eléonore Bettacchioli, Alain Saraux, Alice Tison, Divi Cornec, more

Arthritis & Rheumatology > 76 > 5 > 751 - 762

Objective The biologic diagnosis of primary Sjögren disease (SjD) mainly relies on anti‐Ro60/SSA antibodies, whereas the significance of anti‐Ro52/TRIM21 antibodies currently remains unclear. The aim of this study was to characterize the clinical, serological, biologic, transcriptomic, and interferon profiles of patients with SjD according to their anti‐Ro52/TRIM21 antibody status. Methods Patients...

article

Trends in opioid utilization in Hungary, 2006–2020: A nationwide retrospective study with multiple metrics

Zsófia Engi, Ria Benkő, Gyöngyvér Soós, Délia Szok, more

European Journal of Pain > 26 > 9 > 1896 - 1909

Background Opioid use is well documented in several countries: some countries struggle with overuse, whereas others have almost no access to opioids. For Europe, limited data are available. This study analysed Hungarian opioid utilization in ambulatory care between 2006 and 2020. Methods We obtained national drug utilization data on reimbursed opioid analgesics (ATC code: N02A) from a national...

article

Expression Quantitative Trait Locus Analysis in Systemic Sclerosis Identifies New Candidate Genes Associated With Multiple Aspects of Disease Pathology

Martin Kerick, David González‐Serna, Elena Carnero‐Montoro, Maria Teruel, more

Arthritis & Rheumatology > 73 > 7 > 1288 - 1300

Objective To identify the genetic variants that affect gene expression (expression quantitative trait loci [eQTLs]) in systemic sclerosis (SSc) and to investigate their role in the pathogenesis of the disease. Methods We performed an eQTL analysis using whole‐blood sequencing data from 333 SSc patients and 524 controls and integrated them with SSc genome‐wide association study (GWAS) data. We integrated...

article

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

Guillermo Barturen, Sepideh Babaei, Francesc Català‐Moll, Manuel Martínez‐Bueno, more

Arthritis & Rheumatology > 73 > 6 > 1073 - 1085

Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could be classified into groups defined by molecular pattern. This study was undertaken to identify molecular clusters for reclassifying systemic autoimmune diseases independently of clinical diagnosis. Methods Unsupervised clustering...

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Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5′‐Azacytidine

Dániel M. Tóth, Timea Ocskó, Attila Balog, Adrienn Markovics, more

Arthritis & Rheumatology > 71 > 8 > 1265 - 1275

Objective Disease‐associated, differentially hypermethylated regions have been reported in rheumatoid arthritis (RA), but no DNA methyltransferase inhibitors have been evaluated in either RA or any animal models of RA. The present study was conducted to evaluate the therapeutic potential of 5′‐azacytidine (5′‐azaC), a DNA methyltransferase inhibitor, and explore the cellular and gene regulatory networks...

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The role of B7 family costimulatory molecules and indoleamine 2,3-dioxygenase in primary Sjögren’s syndrome and systemic sclerosis

Nóra Legány, László Berta, László Kovács, Attila Balog, more

Immunologic Research > 2017 > 65 > 3 > 622-629

B7 costimulatory molecules are present on antigen-presenting cells (APCs) and influence intracellular expression of indoleamine 2,3-dioxygenase (IDO), a molecule with important immunoregulatory functions. We determined the frequency of activated (CD11b+) monocytes expressing B7-1, B7-2, B7-H1, and B7-H2 molecules, and that of CD3+ and CD4+ T cells expressing the corresponding CD28, CTLA-4, PD-1, and...

article

Calcium influx kinetics, and the features of potassium channels of peripheral lymphocytes in primary Sjögren’s syndrome

Nóra Legány, Gergely Toldi, Csaba Orbán, Nóra Megyes, more

Immunobiology > 2016 > 221 > 11 > 1266-1272

The transient increase of the cytoplasmic free calcium level plays a key role in the process of lymphocyte activation. Kv1.3 and IKCa1 potassium channels are important regulators of the maintenance of calcium influx and present a possible target for selective immunomodulation.Case–control study.We took peripheral blood samples from 8 healthy individuals and 15 primary Sjögren’s syndrome (pSS) patients...

article

Postural control in degenerative diseases of the hip joint

Edit Sziver, Edit Nagy, Andrea Preszner-Domján, Gabriella Pósa, more

Clinical Biomechanics > 2016 > 35 > C > 1-6

Few studies investigated the postural control in patients with hip joint impairments; in some cases, balance impairments have been found, while other researchers have seen no significant changes. The goal of this study was to characterize postural stability in patients suffering from unilateral osteoarthritis or rheumatoid arthritis in different balance tasks and to reveal potential differences between...

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The effects of Kv1.3 and IKCa1 channel inhibition on cytokine production and calcium influx of T lymphocytes in rheumatoid arthritis and ankylosing spondylitis

Gergely Toldi, Luis Munoz, Martin Herrmann, Georg Schett, more

Immunologic Research > 2016 > 64 > 2 > 627-631

Kv1.3 and IKCa1 lymphocyte potassium channels have been implicated as important targets of selective immunomodulation. We compared the alterations in cytokine production upon selective inhibition of Kv1.3 or IKCa1 channels (by MGTX and TRAM, respectively) in healthy donors (HD), RA and AS patients. We also determined calcium influx kinetics and its sensitivity to Kv1.3 and IKCa1 channel inhibition...

article

Alterations of the thrombin generation profile in rheumatoid arthritis

Anita Kern, Attila Balog, Sonja Dulic, Eszter Barabás, more

Journal of Thrombosis and Thrombolysis > 2016 > 41 > 3 > 359-364

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder resulting in the erosion of the cartilage and bone. Systemic involvement including the cardiovascular system with the risk of atherosclerosis may also occur. Calibrated automated thrombogram (CAT), a commercially available thrombin generation assay is suitable for the general assessment of the functionality of coagulation system...

article

The impact of conventional DMARD and biological therapies on CD4+ cell subsets in rheumatoid arthritis: a follow-up study

Balázs Szalay, Barna Vásárhelyi, Áron Cseh, Tivadar Tulassay, more

Clinical Rheumatology > 2014 > 33 > 2 > 175-185

Rheumatoid arthritis (RA) is an autoimmune disease characterized by abnormal prevalence of Th1, Th2, Th17, and regulatory (Treg) subsets. Some data suggest that these subsets are influenced by anti-RA agents. Follow-up studies monitoring T cell phenotype in response to therapy are limited. We investigated the alteration of CD4+ T cell subset distribution after the initiation of disease-modifying antirheumatic...

article

Taux plasmatiques du récepteur soluble de l’urokinase plasminogène activateur (suPAR) dans la spondylarthrite ankylosante

Gergely Toldi, Balázs Szalay, Gabriella Bekő, László Kovács, more

Revue du rhumatisme > 2013 > 80 > 2 > 179-182

Des études récentes ont démontré que le récepteur soluble de l’urokinase plasminogène activateur (suPAR) est un marqueur précieux à la reconnaissance d’une réponse inflammatoire. Une inflammation en cours entraîne des taux plasmatiques élevés de suPAR. Notre objectif était de définir les taux plasmatiques de suPAR chez les patients atteints de spondylarthrite ankylosante (SA) face à des individus...

article

The effects of Kv1.3 and IKCa1 potassium channel inhibition on calcium influx of human peripheral T lymphocytes in rheumatoid arthritis

Gergely Toldi, Anna Bajnok, Diána Dobi, Ambrus Kaposi, more

Immunobiology > 2013 > 218 > 3 > 311-316

The transient increase of the cytoplasmic free calcium level plays a key role in the process of lymphocyte activation. Kv1.3 and IKCa1 potassium channels are important regulators of the maintenance of calcium influx during lymphocyte activation and present a possible target for selective immunomodulation.Case–control study.We took peripheral blood samples from 10 healthy individuals and 9 recently...

article

Analysis by flow cytometry of calcium influx kinetics in peripheral lymphocytes of patients with rheumatoid arthritis

Anna Bajnok, Ambrus Kaposi, László Kovács, Barna Vásárhelyi, more

Cytometry Part A > 83A > 3 > 287 - 293

The transient increase of the cytoplasmic free calcium level in T lymphocytes plays a key role in initiating and maintaining the autoimmune reaction in rheumatoid arthritis (RA). Kv1.3 and IKCa1 potassium channels are important regulators of the maintenance of calcium influx during lymphocyte activation and present a possible target for selective immunomodulation. We aimed to compare peripheral T...

article

Flow cytometric analysis of procalcitonin expression in human monocytes and granulocytes

Attila Balog, Imre Ocsovszki, Yvette Mándi

Immunology Letters > 2002 > 84 > 3 > 199 - 203

Procalcitonin (PCT), a precursor of calcitonin is a useful indicator of severe systemic infection and sepsis. For a better understanding of the pathophysiological background of PCT induction, a study was made of the intracellular expression of PCT in various human white blood cell populations-i.e. monocytes and polymorphonuclear granulocytes (PMNs)-and the role of TNF-α in the stimulation of their...

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