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Objective and design The aim of this study was to determine potential effects of gold (+) and gold (−) nanoparticles, AuNP(+) and AuNP(−), on neutrophil biology. Material or subjects Freshly isolated human neutrophils were used for the in vitro aspects and CD-1 mice were used in the in vivo murine air pouch model of acute neutrophilic inflammation. Treatment Human neutrophils were treated with...
Nowadays, silver nanoparticles (AgNP) are widely used in the medical field mainly for their antibacterial properties. Although some studies report a cytotoxic activity of the particles, the mechanisms involved in AgNP-induced cell death remain to be determined. Herein, we report that AgNP of 2 (AgNP2) and 15 nm (AgNP15) induce apoptosis in human MCF-7 and T-47D breast cancer cells. Treatment with...
Objective and design The aim of this study was to determine whether different generations (G) polyamidoamine (PAMAM) dendrimers possess proinflammatory activities in vivo. Material or subjects Several hundred female CD-1 mice were used to test four different PAMAM dendrimers using the murine air pouch model. Treatment Mice received appropriate negative and positive controls or G0-G3 PAMAM nanoparticles...
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