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Background The clinical and biological characteristics of metachronous esophageal squamous cell cancer (ESCC) after gastrectomy for gastric cancer have yet to be sufficiently elucidated. The aim of the present study was to examine carcinogenesis in such patients. Methods Subjects comprised 11 patients with metachronous carcinoma in whom ESCC occurred after gastric cancer (metachronous ESCC), 9 patients...
Bax and Bcl-X L genes play an important role in the apoptotic pathway. These expressions were immunohistochemically investigated in 111 patients with advanced esophageal squamous cell carcinoma. The positive rates of p53, Bax, and Bcl-X L were 42.3, 38.7, and 46.8%, respectively. The expression of both Bax and Bcl-X L was not related to clinicopathological findings, including...
The p53 gene is associated with G1 arrest during the cell cycle and with apoptosis. To evaluate the preoperative chemotherapeutic effect in esophageal squamous cell carcinoma, we retrospectively investigated the apoptotic index (AI) and Ki-67 labeling index (Ki-67LI) in relation to the expression of p53. Thirty patients with esophageal carcinoma who had received chemotherapy prior to surgery were...
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