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Abstract To determine whether tobacco smoke (TS) is genotoxic for lung tissue macrophages (pulmonary alveolar macrophages, PAM) as a general result of its inhalatory action BD6 rats, Syrian golden hamsters and BDF1 (C57BlxDBA2) mice were subjected to whole-body exposure for 90 or 60 min daily (600 cm3 mainstream smoke in 16-l glass chamber, 9 or 6 exposures of 15min each, respectively), for different...