Search results for: Jan Haas

Items from 1 to 20 out of 33 results

article

Association between travel time to delivery unit and unplanned out‐of‐hospital birth, infant morbidity and mortality: A population‐based cohort study

Anne K. Örtqvist, Jan Haas, Mia Ahlberg, Mikael Norman, more

Acta Obstetricia et Gynecologica Scandinavica > 100 > 8 > 1478 - 1489

Introduction Over the last decade, a number of delivery units have been closed in Sweden, justified by both economic incentives and patient safety issues. However, concentrating births to larger delivery units naturally increases travel time for some parturient women, which may lead to unintended negative consequences. We aimed to investigate the association between travel time to delivery unit and...

article

Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals

Elham Kayvanpour, Farbod Sedaghat-Hamedani, Weng-Tein Gi, Oguz Firat Tugrul, more

Clinical Research in Cardiology > 2019 > 108 > 11 > 1297-1308

Background Left ventricular non-compaction has been increasingly diagnosed in recent years. However, it is still debated whether non-compaction is a pathological condition or a physiological trait. In this meta-analysis and systematic review, we compare studies, which investigated these two different perspectives. Furthermore, we provide a comprehensive overview on the clinical outcome as well as...

article

Comparative genotyping and phenotyping of Aspergillus fumigatus isolates from humans, dogs and the environment

Ivan D. Valdes, Joris van den Berg, Annika Haagsman, Natalia Escobar, more

BMC Microbiology > 2018 > 18 > 1 > 1-11

Background Aspergillus fumigatus is a ubiquitous saprotrophic fungus and an opportunistic pathogen of humans and animals. Humans and animals can inhale hundreds of A. fumigatus spores daily. Normally this is harmless for humans, but in case of immunodeficiency, invasive pulmonary aspergillosis (IPA) can develop with a high mortality rate. A. fumigatus also causes non-invasive mycoses like sino-nasal...

article

Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes

Katrin Streckfuss-Bömeke, Malte Tiburcy, Andrey Fomin, Xiaojing Luo, more

Journal of Molecular and Cellular Cardiology > 2017 > 113 > C > 9-21

The ability to generate patient-specific induced pluripotent stem cells (iPSCs) provides a unique opportunity for modeling heart disease in vitro. In this study, we generated iPSCs from a patient with dilated cardiomyopathy (DCM) caused by a missense mutation S635A in RNA-binding motif protein 20 (RBM20) and investigated the functionality and cell biology of cardiomyocytes (CMs) derived from patient-specific...

article

Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals

Farbod Sedaghat-Hamedani, Elham Kayvanpour, Oguz Firat Tugrul, Alan Lai, more

Clinical Research in Cardiology > 2018 > 107 > 1 > 30-41

Background Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease, which goes along with increased risk for sudden cardiac death (SCD). Despite the knowledge about the different causal genes, the relationship between individual genotypes and phenotypes is incomplete. Methods and results We retrieved PubMed/Medline literatures on genotype–phenotype associations in patients...

article

Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy

Thomas Borchert, Daniela Hübscher, Celina I. Guessoum, Tuan-Dinh D. Lam, more

Journal of the American College of Cardiology > 2017 > 70 > 8 > 975-991

Takotsubo syndrome (TTS) is characterized by an acute left ventricular dysfunction and is associated with life-threating complications in the acute phase. The underlying disease mechanism in TTS is still unknown. A genetic basis has been suggested to be involved in the pathogenesis.The aims of the study were to establish an in vitro induced pluripotent stem cell (iPSC) model of TTS, to test the hypothesis...

article

DISTURBED EXPRESSION OF IMMUNOREGULATORY LONG NONCODING RNAS IN CIRCULATING IMMUNE CELLS FROM PATIENTS WITH EARLY MYOCARDIAL INFARCTION

Wolfgang Poller, Martina Gast, Shinichi Nakagawa, Jan Haas, more

Journal of the American College of Cardiology > 2017 > 69 > 11(S) > 2036

article

DEFICIENCY OF LONG NONCODING RNA MALAT1 CAUSES IMMUNE SYSTEM DEREGULATION AND ACCELERATED ATHEROSCLEROSIS IN APO E-/- MICE

Wolfgang Poller, Martina Gast, Bernhard Rauch, Shinichi Nakagawa, more

Journal of the American College of Cardiology > 2017 > 69 > 11(S) > 2031

article

Meeting abstracts from the first European Emergency Medical Services congress (EMS2016)

Alexander White, Han Xian Ng, Wai Yee Ng, Eileen Kai Xin Ng, more

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine > 2017 > 25 > 1 > 1-14

article

Mapping and Monitoring Urban Ecosystem Services Using Multitemporal High-Resolution Satellite Data

Jan Haas, Yifang Ban

IEEE Journal of Selected Topics in Applied Earth Observations and Remote... > 2017 > 10 > 2 > 669 - 680

This study aims at providing a new method to efficiently analyze detailed urban ecological conditions at the example of Shanghai, one of the world's most densely populated megacities. The main objective is to develop a method to effectively analyze high-resolution optical satellite data for mapping of ecologically important urban space and to evaluate ecological changes through the emerging ecosystem...

article

A self-taught artificial agent for multi-physics computational model personalization

Dominik Neumann, Tommaso Mansi, Lucian Itu, Bogdan Georgescu, more

Medical Image Analysis > 2016 > 34 > C > 52-64

Personalization is the process of fitting a model to patient data, a critical step towards application of multi-physics computational models in clinical practice. Designing robust personalization algorithms is often a tedious, time-consuming, model- and data-specific process. We propose to use artificial intelligence concepts to learn this task, inspired by how human experts manually perform it. The...

article

Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals

Elham Kayvanpour, Farbod Sedaghat-Hamedani, Ali Amr, Alan Lai, more

Clinical Research in Cardiology > 2017 > 106 > 2 > 127-139

Aims Routine genetic testing in Dilated Cardiomyopathy (DCM) has recently become reality using Next-Generation Sequencing. Several studies have explored the relationship between genotypes and clinical phenotypes to support risk estimation and therapeutic decisions, however, most studies are small or restricted to a few genes. This study provides to our knowledge the first systematic meta-analysis...

article

Hide and Seek: Protein-coding Sequences Inside “Non-coding” RNAs

Daniel Oehler, Jan Haas

Genomics, Proteomics & Bioinformatics > 2016 > 14 > 4 > 179-180

article

The Role of Quality Control in Targeted Next-generation Sequencing Library Preparation

Rouven Nietsch, Jan Haas, Alan Lai, Daniel Oehler, more

Genomics, Proteomics & Bioinformatics > 2016 > 14 > 4 > 200-206

Next-generation sequencing (NGS) is getting routinely used in the diagnosis of hereditary diseases, such as human cardiomyopathies. Hence, it is of utter importance to secure high quality sequencing data, enabling the identification of disease-relevant mutations or the conclusion of negative test results. During the process of sample preparation, each protocol for target enrichment library preparation...

article

Validating Alzheimer's disease micro RNAs using next-generation sequencing

Andreas Keller, Christina Backes, Jan Haas, Petra Leidinger, more

Alzheimer's & Dementia > 2016 > 12 > 5 > 565-576

Molecular biomarkers for Alzheimer's disease (AD) can support detection and improved care for patients, but novel candidates require verification. We previously reported a 12-micro RNA (miRNA) blood-based signature using next-generation sequencing (NGS) of 54 AD cases and 22 controls.We performed validation of 49 AD cases and 55 controls using NGS and also included 20 mild cognitive impairment and...

chapter

CONTASK: Context-Sensitive Task Assistance in the Semantic Desktop

Heiko Maus, Sven Schwarz, Jan Haas, Andreas Dengel

Lecture Notes in Business Information Processing > Enterprise Information Systems > Part II: Artificial Intelligence and Decision Support Systems > 177-192

In knowledge work, users are confronted with difficulties in remembering, retrieving, and accessing relevant information and knowledge for their task at hand. In addition, knowledge-intensive, task-oriented work is highly fragmented and, therefore, requires knowledge workers to effectively handle and recover from interruptions. The Semantic Desktop approach provides an environment to represent,...

article

Diagnosis and management of aspergillosis in the Netherlands: a national survey

Pieter P. A. Lestrade, Jacques F. Meis, Jan P. Arends, Martha T. Beek, more

Mycoses > 59 > 2 > 101 - 107

A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non‐academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between...

article

Deep characterization of blood cell miRNomes by NGS

Eva C. Schwarz, Christina Backes, Arne Knörck, Nicole Ludwig, more

Cellular and Molecular Life Sciences > 2016 > 73 > 16 > 3169-3181

A systematic understanding of different factors influencing cell type specific microRNA profiles is essential for state-of-the art biomarker research. We carried out a comprehensive analysis of the biological variability and changes in cell type pattern over time for different cell types and different isolation approaches in technical replicates. All combinations of the parameters mentioned above...

article

Objective classification and comparison of OHCA and AED locations using geographic information systems

David Fredman, Jan Haas, Yifang Ban, Martin Jonsson, more

Resuscitation > 2015 > 96 > S1 > 21

article

Satellite monitoring of urbanization and environmental impacts—A comparison of Stockholm and Shanghai

Jan Haas, Dorothy Furberg, Yifang Ban

International Journal of Applied Earth Observations and Geoinformation > 2015 > 38 > Complete > 138-149

This study investigates urbanization and its potential environmental consequences in Shanghai and Stockholm metropolitan areas over two decades. Changes in land use/land cover are estimated from support vector machine classifications of Landsat mosaics with grey-level co-occurrence matrix features. Landscape metrics are used to investigate changes in landscape composition and configuration and to...

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INFONA - science communication portal

Search results for: Jan Haas

Association between travel time to delivery unit and unplanned out‐of‐hospital birth, infant morbidity and mortality: A population‐based cohort study

Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals

Comparative genotyping and phenotyping of Aspergillus fumigatus isolates from humans, dogs and the environment

Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes

Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals

Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy

DISTURBED EXPRESSION OF IMMUNOREGULATORY LONG NONCODING RNAS IN CIRCULATING IMMUNE CELLS FROM PATIENTS WITH EARLY MYOCARDIAL INFARCTION

DEFICIENCY OF LONG NONCODING RNA MALAT1 CAUSES IMMUNE SYSTEM DEREGULATION AND ACCELERATED ATHEROSCLEROSIS IN APO E-/- MICE

Meeting abstracts from the first European Emergency Medical Services congress (EMS2016)

Mapping and Monitoring Urban Ecosystem Services Using Multitemporal High-Resolution Satellite Data

A self-taught artificial agent for multi-physics computational model personalization

Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals

Hide and Seek: Protein-coding Sequences Inside “Non-coding” RNAs

The Role of Quality Control in Targeted Next-generation Sequencing Library Preparation

Validating Alzheimer's disease micro RNAs using next-generation sequencing

CONTASK: Context-Sensitive Task Assistance in the Semantic Desktop

Diagnosis and management of aspergillosis in the Netherlands: a national survey

Deep characterization of blood cell miRNomes by NGS

Objective classification and comparison of OHCA and AED locations using geographic information systems

Satellite monitoring of urbanization and environmental impacts—A comparison of Stockholm and Shanghai

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