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Abstract. Introduction: MDX-H210 is a FabFab bispecific antibody (BsAb) constructed chemically by crosslinking Fab mAb 520C9 (anti-HER-2/neu) and humanized Fab mAbH22 (anti-CD64). Study design and objectives: This was a phase I dose-escalation study of intravenous MDX-H210 (170mg/m2) combined with subcutaneous IFN-, 50g/m2 given 24h before the BsAb, both drugs being given three times a week for 3weeks...
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