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“Life manifests in duality” is a philosophical tenet in many cultures. This idea is embodied clearly by the Asian concept of yin and yang, in which the complementary forces of dark (yin) and light (yang) govern all aspects of life. Yin and yang convey the interdependence of opposites. Such reciprocity is a common feature of many biological processes - including skeletal maintenance.
Recent efforts to understand breast cancer biology involve three interrelated themes that are founded on a combination of clinical and experimental observations. The central concept is gene addiction. The clinical dilemma is the escape from gene addiction, which is mediated, in part, by phenotypic plasticity as exemplified by epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition...
Introduction Rats with adjuvant-induced arthritis (AIA) were necropsied on 14 occasions during preclinical, acute clinical and chronic clinical stages of AIA progression to characterize local (joint protein extracts) and systemic (serum) levels of mediators regulating inflammation and bone erosion in conjunction with lymphoid tissue-specific leukocyte kinetics. Results Systemic increases in alpha1...
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