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Abstract. Objective: The effects of coadministration of the non-steroidal anti-inflammatory drug diflunisal (DF) on glucuronidation and -oxidation of the anti-epileptic agent valproic acid (VPA), and of VPA on DF glucuronidation, were studied in human volunteers. Methods: Seven healthy male volunteers received sodium valproate (NaVPA, 200mg) orally twice daily for 7days, after which all drug intake...
. Objective: The effects of coadministration of the non-steroidal anti-inflammatory drug diflunisal (DF) on glucuronidation and β-oxidation of the anti-epileptic agent valproic acid (VPA), and of VPA on DF glucuronidation, were studied in human volunteers. Methods: Seven healthy male volunteers received sodium valproate (NaVPA, 200 mg) orally twice daily for 7 days, after which all drug intake ceased...
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