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In order to mimic the neutralizing potency of polyclonal antibodies, combinations of neutralizing monoclonal antibodies (mAbs) are used. The main pre-requisite of any preparation which is comprised of several neutralizing mAb is that its antibodies will target distinct epitopes on the antigen molecule. The aim of this study was to elucidate a mixture of antibodies that exhibits a synergistic protective-antigen...
The Variola virus is the causative agent of smallpox disease. Accurate identification of Variola and differential diagnosis between Variola and other vesicle forming (smallpox-like) pathogens are both technically challenging and of great importance. We compiled a list of vesicle forming pathogens that are prone to be misdiagnosed as smallpox. Some of the pathogens (members of the Orthopoxvirus genus)...
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