Search results for: Stanisław Ostrowski

Items from 1 to 11 out of 11 results

article

A vicarious approach to porphyrin aldehydes

Stanisław Ostrowski, Magdalena Kosmalska, Agnieszka Mikus

Tetrahedron Letters > 2017 > 58 > 21 > 2011-2013

The novel synthesis of nitro-porphyrin aldehydes via vicarious nucleophilic substitution of hydrogen in the corresponding nitro-meso-tetraphenylphyrinates (Zn^II, Cu^II) with haloform carbanions, followed by hydrolysis of the introduced dihalomethyl groups under mild conditions (H₂O–toluene, AgClO₄, reflux) is described.

article

Can the onset of heart failure be delayed by treating diabetic cardiomyopathy?

Anna Marcinkiewicz, Stanisław Ostrowski, Józef Drzewoski

Diabetology & Metabolic Syndrome > 2017 > 9 > 1 > 1-7

The pathophysiology of diabetic cardiomyopathy (DC) is not fully understood. This frequently undiagnosed complication of chronic hyperglycemia leads to heart failure (HF). However, it is suggested that an appropriate metabolic control of diabetes at an early stage of this deleterious disease, is able to inhibit the development and progression of DC to HF. Recently, it has been postulated that myocardial...

chapter

Multi-Component Reactions in Supramolecular Chemistry and Material Science

Ludger A. Wessjohann, Stanisław Ostrowski, Vasiliy Bakulev, Vera Berseneva, more

Advances in Experimental Medicine and Biology > MCR 2009 > 173-201

Multi-component reactions of building blocks with more than one MCR-reactive group will give rise to oligomeric MCR products. The proper choice of at least two bifunctional building blocks will give either a polymeric or a cyclic product. Apart from polymerization, repetitive or consecutive Ugi reactions have been used to produce linear MCR-heterooligomers with such building blocks.

article

Left atrio-esophageal fistula of a possibly iatrogenic aetiology

Piotr Arkuszewski, Maciej Barzdo, Stanisław Ostrowski, Stefan Szram, more

Forensic Science International > 2015 > 252 > Complete > e1-e5

The study presents an exceptionally rare case of an esophago-left atrial fistula, which was diagnosed during a forensic post-mortem examination. Due to complex nature of the disease and many attempts to cure the patient, the authors did not manage to identify the aetiology of the fistula. It was only implied that the fistula might have been a distant complication of intraoperative endocardial ablation...

article

Myocardial oxidative stress in patients with active infective endocarditis

Stanislaw Ostrowski, Marek Kasielski, Jacek Kordiak, Anna Zwolinska, more

International Journal of Cardiology > 2013 > 167 > 1 > 270-276

Infective endocarditis (IE) induces the rise of pro-inflammatory cytokines. Some of them can stimulate oxidants production in myocardium with subsequent peroxidative damage to various biomolecules. We compared indices of oxidative stress: H ₂ O ₂ , thiobarbituric acid-reactive substances (TBARs), thiols in myocardium specimens between patients with active IE and those with valvular...

article

Powikłania krwotoczne z przewodu pokarmowego w przebiegu przewlekłej profilaktyki przeciwzakrzepowej antagonistami witaminy K

Stanisław Ostrowski, Małgorzata Sawa, Małgorzata Zagroda, Andrzej Prystupa, more

Family Medicine & Primary Care Review > 2013 > 3 > 365-367

article

Direct β-amination reaction in porphyrin systems—a simple route to compounds containing two nitrogen substituents at both β-positions of the same pyrrole unit

Stanisław Ostrowski, Sebastian Grzyb

Tetrahedron Letters > 2012 > 53 > 47 > 6355-6357

The direct β-amination of porphyrin derivatives is described. 2-Nitro-meso-tetraarylporphyrins (zinc and copper complexes) react with N,N,N-trimethylhydrazinium iodide (TMHI) in the presence of a base (KOH/DMSO system, ca 70–80°C) to give products of nucleophilic aromatic substitution of hydrogen. In this process, the nucleophilic replacement of a H-atom by an NH ₂ group takes place. The products...

article

The first example of Diels–Alder cycloaddition of ortho-xylylenes to meso-tetraarylporphyrins containing electron-deficient β,β-double bonds

Stanisław Ostrowski, Przemysław Wyrębek

Tetrahedron Letters > 2006 > 47 > 47 > 8437-8440

β-Nitro-5,10,15,20-tetraphenylporphyrin and its zinc complex, or 2,7-dinitro-5,10,15,20-tetraphenylporphyrin, react with 1,3-dihydrobenzo[c]thiophene 2,2-dioxide in refluxing 1,2,4-trichlorobenzene, giving rise to chlorins, bacteriochlorins or isobacteriochlorins. The products obtained are attractive intermediates for further functionalization of porphyrins and may be of potential use as sensitizers...

article

Synthesis of highly substituted meso-tetraarylporphyrins

Stanisław Ostrowski, Agnieszka Mikus, Beata Łopuszyńska

Tetrahedron > 2004 > 60 > 51 > 11951- 11957

meso-Tetraphenylporphyrin (and its derivatives), in the reaction with fuming yellow nitric acid (d=1.53), form either 5-(4-nitroaryl)-10,15,20-triarylporphyrin, 5,10-bis(4-nitroaryl)-15,20-diarylporphyrin, or 5,10,15-tris(4-nitroaryl)-20-arylporphyrin, depending on the reaction temperature (0–20°C), amounts of the acid used, and reaction time. The above nitroporphyrins react, in the presence of a...

article

A new approach to the synthesis of porphyrin-fullerene dyads

Stanisław Ostrowski, Agnieszka Mikus

Molecular Diversity > 2003 > 6 > 3-4 > 315-321

A new synthetic approach to porphyrin-fullerene dyads utilizing tetraphenylporphyrin (TPP) and three novel reactions (vicarious nucleophilic substitution, metathesis, and [4+2]-cycloaddition to fullerene) is described. 5-(4-Nitrophenyl)-10,15,20-triphenylporphyrin zinc complex reacts with the carbanion of chloromethyl para-tolyl sulphone (which bears a leaving group Cl at the carbanionic center),affording...

article

A synthesis of fused pyrimidine mono-n-oxides

Stanisław Ostrowski

Heterocycles > 1996 > 43 > 2 > 389-396

An efficient synthesis of functionalized fused pyrimidine mono-N-oxide derivatives from the nitroaromatic compounds (involving the Vicarious Nucleophilic Substitution of Hydrogen and cyclocondensation of aromatic orthoaminooximes with orthoesters) is described.

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