Search results for: Jignesh P. Patel

Items from 1 to 20 out of 38 results

article

Synthesis and spectral analysis of (E)-1-(2,4-dihydroxy phenyl)-3-(4-hydroxyphenyl) prop-2-en-1-one

Jalpa V. Chopda, Jignesh P. Patel, Parsotam H. Parsania

World News of Natural Sciences > 2023 > 46 > 46-52

Multifunction chalcone: (E)-1-(2,4-dihydroxy phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (THCH) was synthesized by reacting a 0.01 mol 2,4-dihydroxy acetophenone, and a 0.01 mol 4-hydroxybenzaldehyde using 10 ml of 60% aq. sodium hydroxide as a catalyst and 25 ml of ethanol as a solvent at reflux temperature for 3h. The THCH was crystallized using a water-methanol system. The structure of THCH was...

article

Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease

Mandy Wan, Bruce Green, Arpana Aprameya Iyengar, Nivedita Kamath, more

British Journal of Clinical Pharmacology > 88 > 3 > 1223 - 1234

Aims The prevalence of vitamin D deficiency is high in children with chronic kidney disease (CKD). However, current dosing recommendations are based on limited pharmacokinetic (PK) data. This study aimed to develop a population PK model of colecalciferol that can be used to optimise colecalciferol dosing in this population. Methods Data from 83 children with CKD were used to develop a population...

article

Synthesis, the spectral and thermal analysis of (2E,5E)2,5-bis(3R,5R-4-hydroxy benzylidene)cyclopentanone

Dharmesh B. Sankhavara, Jignesh P. Patel, Parsotam H. Parsania

World Scientific News > 2022 > 174 > 161-176

(2E,5E)2,5-Bis(3R,5R-4-hydroxy benzylidene)cyclopentanone (BHCP: R=H and BrBHCP: R=Br) was synthesized by reacting 4-hydroxybenzaldehyde with cyclopentanone using boric acid (in hydrochloric acid) as a catalyst at 60-70 °C for 1h. BHCP was brominated in glacial acetic acid at reflux temperature for 1h. The structures of BHCP and BrBHCP were supported by spectral techniques: UV-Visible, FTIR, 1HNMR,...

article

Fixed dose rivaroxaban can be used in extremes of bodyweight: A population pharmacokinetic analysis ‐ Reply to Jacobs & Ryan comment

Victoria Speed, Lara N. Roberts, Roopen Arya, Jignesh P. Patel

Journal of Thrombosis and Haemostasis > 19 > 3 > 872 - 873

article

Quality and use of unlicensed vitamin D preparations in primary care in England: Retrospective review of national prescription data and laboratory analysis

Mandy Wan, Anish Patel, Jignesh P. Patel, Greta Rait, more

British Journal of Clinical Pharmacology > 87 > 3 > 1338 - 1346

Aim To evaluate the type (licensed vs unlicensed) and cost of preparations used to fulfil vitamin D prescriptions in England over time, and to compare measured vitamin D content of selected vitamin D preparations against labelled claim. Methods Retrospective analysis of vitamin D prescription data in primary care in England (2008‐2018). Laboratory analysis of 13 selected vitamin D preparations...

article

More on enoxaparin thromboprophylaxis in pregnancy: A review of 10 years' experience from King's College Hospital

Nissalini Rajaratnam, Jignesh P. Patel, Lara N. Roberts, Julia Czuprynska, more

Journal of Thrombosis and Haemostasis > 19 > 1 > 304 - 308

article

Potential comparison of montmorillonite filled and unfilled epoxy methacrylate of bisphenol-C-glass/ jute/treated jute and hybrid composites

Ritesh D. Bhatt, Jignesh P. Patel, Parsotam H. Parsania

World Scientific News > 2021 > 158 > 227-246

Montmorillonite filled and unfilled controls, jute/treated jute/glass/hybrid composites were prepared at room temperature for three h and under 5 MPa pressure. The composites were post cured at 150 °C for 30 min. A 40% styrene was used as a reactive diluent, and 1% methylethylketone peroxide, 1.5 % cobalt octoate, and 1.5% dimethylaniline were used as initiator and accelerator, and a promoter. Filled...

article

Fixed dose rivaroxaban can be used in extremes of bodyweight: A population pharmacokinetic analysis

Victoria Speed, Bruce Green, Lara N. Roberts, Sarah Woolcombe, more

Journal of Thrombosis and Haemostasis > 18 > 9 > 2296 - 2307

Background Emerging safety and efficacy data for rivaroxaban suggest traditional therapy and rivaroxaban are comparable in the morbidly obese. However, real‐world data that indicate pharmacokinetic (PK) parameters are comparable at the extremes of body size are lacking. The International Society of Thrombosis and Haemostasis Scientific and Standardisation Committee (ISTH SSC) suggests avoiding the...

article

What are the difficulties in conducting randomised controlled trials of thromboprophylaxis in myeloma patients and how can we address these? Lessons from apixaban versus LMWH or aspirin as thromboprophylaxis in newly diagnosed multiple myeloma (TiMM) feasibility clinical trial

Zara Sayar, Julia Czuprynska, Jignesh P. Patel, Reuben Benjamin, more

Journal of Thrombosis and Thrombolysis > 2019 > 48 > 2 > 315-322

Routine thromboprophylaxis (TP) in newly-diagnosed multiple myeloma (NDMM) patients comprises either aspirin for standard risk patients or low molecular weight heparin for high risk patients. Studies using DOACs in cancer patients include few with myeloma. The aim of this feasibility clinical trial was to establish the foundations for creating a multicentre trial and identify any safety concerns with...

article

Progress in the monitoring of direct oral anticoagulant therapy

Jignesh P. Patel, Rosalind A. Byrne, Raj K. Patel, Roopen Arya

British Journal of Haematology > 184 > 6 > 912 - 924

The availability of direct oral anticoagulants (DOACs) has led to a paradigm shift in the field of anticoagulation, with DOACs increasingly being prescribed for patients in preference to vitamin K antagonists and low molecular weight heparin. Despite good experience with the use of these agents at fixed doses, there are clinical scenarios where monitoring is recommended. Data from phase III studies...

article

Prothrombin times in the presence of edoxaban – in‐vivo experience from King's College hospital

Jignesh P. Patel, Paradzai B. Chitongo, Preetam Dighe, Lara N. Roberts, more

British Journal of Haematology > 184 > 3 > 455 - 456

article

Synthesis, spectral and thermal study of (2E, 6E) 2,6-bis(4-hydroxy benzylidene)-4-R-cyclohexanone

Dharmesh B. Sankhavara, Jalpa V. Chopda, Jignesh P. Patel, P. H. Parsania

World Scientific News > 2019 > 123 > 141-160

(2E,6E) 2,6-Bis(4-hydroxybenzalidene)-4-R-cyclohexanone (BHBC, R = H and MBHBC, R = CH3) was synthesized by condensing cyclohexanone/4-methylcyclohexanone with 4-hydroxy benzaldehyde using mixture of boric acid and hydrochloric acid as a catalyst at 60-70 ºC for 1 h. The structures of BHBC and MBHBC are supported by FTIR, 1HNMR, 13CNMR and MS techniques. DSC endothermic transition at 282.48 ºC (BHBC)...

article

Preparation and performance evaluation of jute and glass composites of epoxy resin of (2E,6E)-2,6-bis (4-hydroxy benzylidene)-4-methylcyclohexanone

Jalpa V. Chopda, Dharmesh B. Sankhavara, Jignesh P. Patel, P. H. Parsania

World Scientific News > 2019 > 129 > 23-39

Jute and glass composites were prepared by compressing molding technique at 150C for 3h under 20 MPa pressure. J-EMBHBC-DDS, J-EMBHBC-THPA, G-EMBHBC-DDS and G-EMBHBC-THPA showed 15, 15.1, 58.3 and 18.7 MPa tensile strength, respectively. J-EMBHBC-DDS and J-EMBHBC-THPA showed 22.9 and 19.4 MPa flexural strength, respectively. J-EMBHBC-DDM and G-EMBHBC-DDM showed 1.6×109 and 1.2×1012 ohm cm volume...

article

Synthesis, spectral and thermal study of (2E,6E)-2,6-bis(4-aminobenzylidene)cyclohexanone

Jignesh P. Patel, P. H. Parsania

World Scientific News > 2019 > 124 > 2 > 312-318

(2E,6E)-2,6-bis(4-aminobenzylidene)cyclohexanone (BABC) was synthesized by two-step reaction of p-nitrobenzaldehyde and cyclohexanone followed by its reduction. The structure of BABC was supported by UV-Vis, FTIR, 1HNMR and mass spectral data. DSC endothermic transition at 230.6 ºC is assigned as melting transition followed by decomposition reaction. BABC is thermally stable up to 240 ºC and followed...

article

Effect of temperature and solvents on ultrasonic speed and thermo-acoustic parameters of epoxy resin of (2E, 6E)-bis (4-hydroxy benzylidene)-4-methylcyclohexanone solutions at four different temperatures

Jalpa V. Chopda, Dharmesh B. Sankhavara, Jignesh P. Patel, P. H. Parsania

World Scientific News > 2019 > 131 > 222-241

The density (), viscosity () and ultrasonic speed (U) of 1, 4-dioxane (DO), tetrahydrofuran (THF), chloroform (CF) and solutions (0.25-5 wt%) of epoxy resin of (2E, 6E)-bis(4-hydroxy benzylidene)-4-methylcyclohexanone have been investigated at 298, 303, 308 and 313 K to understand molecular interactions in solutions of different polarity. Various acoustical and thermodynamic activation parameters...

article

Venous thromboembolism and women's health

Victoria Speed, Lara N. Roberts, Jignesh P. Patel, Roopen Arya

British Journal of Haematology > 183 > 3 > 346 - 363

The prevention and treatment of venous thromboembolism (VTE) poses distinct gender‐specific challenges. Women of childbearing age are at an increased risk of VTE secondary to the transient risk factors of combined hormonal contraception (CHC) and pregnancy. Cancers specific to women are associated with a significant burden of VTE; whilst the incidence of VTE in localised breast cancer is 5 per 1000...

article

Factors influencing the recruitment of lactating women in a clinical trial involving direct oral anticoagulants: a qualitative study

Yating Zhao, Amally Ding, Roopen Arya, Jignesh P. Patel

International Journal of Clinical Pharmacy > 2018 > 40 > 6 > 1511-1518

Background Robust human data on medication use during lactation is scarce. With increasing medication use in postpartum women, it is important to conduct clinical lactation studies measuring the excretion of drugs in human milk and generate evidence. We plan to conduct a clinical lactation study, involving the direct oral anticoagulants (DOACs). Objective This study aimed to identify factors influencing...

article

Sub therapeutic rivaroxaban plasma concentrations following administration via Percutaneous Endoscopic Gastrostomy (PEG) feeding tubes – A note of caution

Rosalind Byrne, Alison Brown, Jignesh P. Patel, Julia Czuprynska, more

Thrombosis Research > 2018 > 168 > C > 102-103

article

Synthesis of Bisphthalamic Acids for the Preparation of Glass‐Reinforced Composites of Multifunctional Epoxy Resin of Bisphenol‐C and Their Physicochemical Properties

Jignesh P. Patel, Parsotam H. Parsania

Advances in Polymer Technology > 37 > 1 > 275 - 280

Bisphthalamic acids of tetrahydrophthalic anhydride (THPA), tetrachlorophthalic anhydride (TCPA), tetrabromophthalic anhydride (TBPA), and 4,4′‐diamino diphenylsulfone (DDS), 4,4′‐diaminodiphenylether (DDE), and 4,4′‐diaminodiphenyl methane (DDM) were synthesized and used as hardeners for multifunctional epoxy resin of bisphenol‐C(EBCF). Glass‐reinforced composites (G‐EBCF‐THPA, G‐EBCF‐TCPA, G‐EBCF‐TBPA,...

article

Re: Pregnancy outcomes in women with mechanical prosthetic heart valves – a prospective descriptive population‐based study using the United Kingdom Obstetric Surveillance System (UKOSS) data collection system

Jignesh P Patel, Lara N Roberts, Raj K Patel, Roopen Arya

BJOG: An International Journal of Obstetrics & Gynaecology > 125 > 1 > 96 - 96

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Search results for: Jignesh P. Patel

Synthesis and spectral analysis of (E)-1-(2,4-dihydroxy phenyl)-3-(4-hydroxyphenyl) prop-2-en-1-one

Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease

Synthesis, the spectral and thermal analysis of (2E,5E)2,5-bis(3R,5R-4-hydroxy benzylidene)cyclopentanone

Fixed dose rivaroxaban can be used in extremes of bodyweight: A population pharmacokinetic analysis ‐ Reply to Jacobs & Ryan comment

Quality and use of unlicensed vitamin D preparations in primary care in England: Retrospective review of national prescription data and laboratory analysis

More on enoxaparin thromboprophylaxis in pregnancy: A review of 10 years' experience from King's College Hospital

Potential comparison of montmorillonite filled and unfilled epoxy methacrylate of bisphenol-C-glass/ jute/treated jute and hybrid composites

Fixed dose rivaroxaban can be used in extremes of bodyweight: A population pharmacokinetic analysis

What are the difficulties in conducting randomised controlled trials of thromboprophylaxis in myeloma patients and how can we address these? Lessons from apixaban versus LMWH or aspirin as thromboprophylaxis in newly diagnosed multiple myeloma (TiMM) feasibility clinical trial

Progress in the monitoring of direct oral anticoagulant therapy

Prothrombin times in the presence of edoxaban – in‐vivo experience from King's College hospital

Synthesis, spectral and thermal study of (2E, 6E) 2,6-bis(4-hydroxy benzylidene)-4-R-cyclohexanone

Preparation and performance evaluation of jute and glass composites of epoxy resin of (2E,6E)-2,6-bis (4-hydroxy benzylidene)-4-methylcyclohexanone

Synthesis, spectral and thermal study of (2E,6E)-2,6-bis(4-aminobenzylidene)cyclohexanone

Effect of temperature and solvents on ultrasonic speed and thermo-acoustic parameters of epoxy resin of (2E, 6E)-bis (4-hydroxy benzylidene)-4-methylcyclohexanone solutions at four different temperatures

Venous thromboembolism and women's health

Factors influencing the recruitment of lactating women in a clinical trial involving direct oral anticoagulants: a qualitative study

Sub therapeutic rivaroxaban plasma concentrations following administration via Percutaneous Endoscopic Gastrostomy (PEG) feeding tubes – A note of caution

Synthesis of Bisphthalamic Acids for the Preparation of Glass‐Reinforced Composites of Multifunctional Epoxy Resin of Bisphenol‐C and Their Physicochemical Properties

Re: Pregnancy outcomes in women with mechanical prosthetic heart valves – a prospective descriptive population‐based study using the United Kingdom Obstetric Surveillance System (UKOSS) data collection system

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